Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Trained immunity in skin infections: Macrophages and beyond

    Vitka Gres, Merve Göcer ... Philipp Henneke
    Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility

    Shivraj M Yabaji, Vadim Zhernovkov ... Igor Kramnik
    Myc dysregulation in activated macrophages impairs antioxidant defenses, locking them in a vicious cycle that amplifies type I interferon signaling, driving hyperinflammation and immunosuppression.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

    Se-Jin Kim, Jessie C Peterson ... David M Lewinsohn
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cell Biology
    2. Immunology and Inflammation

    Protein phase change batteries drive innate immune signaling and cell fate

    Alejandro Rodriguez Gama, Tayla Miller ... Randal Halfmann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Restoring data balance via generative models of T cell receptors for antigen-binding prediction

    Emanuele Loffredo, Mauro Pastore ... Rémi Monasson
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

    Peter Georgiev, Sheila Johnson ... Arlene H Sharpe
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

    Tianhan Li, Liaoxun Lu ... Lichen Zhang
    Using Xcr1Cre-Gfp Rosa26LSL-DTA Apoe–/– model and Xcl1–/– Apoe–/– mouse model reveal an essential non-redundant role for the XCL1-XCR1 axis in cDC1-mediated atherogenesis.
    1. Immunology and Inflammation

    Type I and type III interferon receptor knockout chickens: Novel models for unraveling interferon dynamics in influenza infection

    Mohanned Naif Alhussien, Hanna-Kaisa Vikkula ... Benjamin Schusser
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Incomplete
    1. Cancer Biology
    2. Immunology and Inflammation

    An evaluation of the tumor microenvironment through CALR, IL1R1, IFNB1, and IFNG to assess prognosis and immunotherapy response in bladder cancer patients

    Lilong Liu, Zhenghao Liu ... Zheng Liu
    A novel risk-scoring model enables personalized treatment decisions for bladder cancer patients.
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