Browse our latest Immunology and Inflammation articles

The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.

Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.

Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.

Systemic neutrophils do not respond to laser-induced photoreceptor damage despite the robust response from resident microglia.

Regulatory T cell expression of layilin mediates adhesion in skin, which acts to attenuate their suppressive capacity.

Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.

Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.