Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Interferon Signaling: Immobilizing bacteria to prevent infections

    Patricia Reist Iscar, Petr Broz
    The interferon-induced GTPase GVIN1 prevents bacteria from spreading among cells by coating them and rendering them immobile.
    Version of Record
    Insight
    1. Immunology and Inflammation

    Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

    Cilia R Pothast, Ian Derksen ... Ferenc A Scheeren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

    Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
    Combining phylogenetic analyses and functional assays to study the receptor interacting protein kinase family reveals conserved and non-conserved functions in immune signaling across vertebrates.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

    Sihui Cai, Jie Zhou ... Jun Cui
    IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m6A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Somatic hypermutation patterns in immunoglobulin variable regions are established independently of the local transcriptional landscape

    Ursula E Schoeberl, Johanna Fitz ... Rushad Pavri
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    T-follicular helper cell profiles differ by malaria antigen and for children compared to adults

    Catherine Suzanne Forconi, Christina Nixon ... Ann M Moormann
    Pf-GARP antigen seems to be a better malaria vaccine candidate compared to PfSEA-1A, as it triggered the activation of cTFH17, involved in the maintenance of memory antibody responses in adults.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses

    Shweta Chaudhary, Mothe Sravya ... Ranjan Kumar Nanda
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Immunology and Inflammation

    Modeling hereditary diffuse leukoencephalopathy with axonal spheroids using microglia-sufficient brain organoids

    Wei Jie Wong, Yi Wen Zhu ... Florent Ginhoux
    Co-culture between donor-derived iPSC-induced macrophages and forebrain organoids revealed microglial impairment leading to the degenerative neuro-environment in HDLS.
    1. Immunology and Inflammation

    Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease

    Lulu Qin, Chongbin Hu ... Jianzhong Shao
    The generation of a Ctla-4-deficient zebrafish line has established a direct link between Ctla-4 and IBD in zebrafish.
    1. Immunology and Inflammation

    Reprogramming of GM-CSF-dependent alveolar macrophages through GSK3 activity modulation

    Israel Ríos, Cristina Herrero ... Angel L Corbí
    Chemical inhibition or genetic downregulation of glycogen synthase kinase-3 reprograms human monocyte-derived macrophages by enhancing their anti-inflammatory, homeostatic, and reparative functions.
    Version of Record
    Research Article
    • Important
    • Compelling
    • Convincing
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