Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation

    Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

    Hella Luksch, Felix Schulze ... Angela Rösen-Wolff
    TNF signaling contributes significantly to pathology of constitutively active STING in murine STING-associated vasculopathy with onset in infancy disease.
    1. Immunology and Inflammation

    Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

    Alannah Lejeune, Chunyi Zhou ... Ken Cadwell
    Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Ab initio prediction of specific phospholipid complexes and membrane association of HIV-1 MPER antibodies by multi-scale simulations

    Colleen A Maillie, Kiana Golden ... Marco Mravic
    Molecular dynamics simulations reveal that lipid binding at antibody loops and framework regions stabilizes membrane interactions, providing molecular details for neutralization mechanisms and strategies for HIV-1 vaccine development.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

    Pavla Nedbalová, Nikola Kaislerova ... Tomáš Doležal
    Adenosine produced by transmethylation may act as a sensor of the balance between cell activity and nutrient supply.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Load-based divergence in the dynamic allostery of two TCRs recognizing the same pMHC

    Ana Cristina Chang-Gonzalez, Aoi Akitsu ... Wonmuk Hwang
    Recognition of antigenic ligand by T-cell receptors is a nuanced process where mechanical force can be leveraged to diversify functional outcomes of different T-cells for the same ligand.
    1. Immunology and Inflammation

    CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

    Xiaoyu Meng, Yezhang Zhu ... Lie Wang
    CXXC1 is a pivotal epigenetic regulator that ensures Treg homeostasis and suppressive function by interacting with FOXP3 to modulate H3K4me3 deposition at key signature genes.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Broad-spectrum immune suppression encoded in self-amplifying RNA enables non-cytotoxic, non-immunostimulatory, externally controllable transgene expression

    Tony KY Lim, Anne Ritoux ... Ewan St John Smith
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Nora virus proliferates in dividing intestinal stem cells and sensitizes flies to intestinal infection and oxidative stress

    Adrien Franchet, Samantha Haller ... Dominique Ferrandon
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Single-cell transcriptomics identifies a dampened neutrophil function and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs

    Gagandeep Kaur, Thomas Lamb ... Irfan Rahman
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    The C3-C3aR axis modulates trained immunity in alveolar macrophages

    Alexander P Earhart, Rafael Aponte Alburquerque ... Hrishikesh S Kulkarni
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
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