Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

   Mohsen Khosravi-Maharlooei, Andrea Vecchione ... Megan Sykes

   Functional analyses identify Tfh-like and Tph-like CD4⁺ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.
2. 1. Immunology and Inflammation
   2. Evolutionary Biology

   Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

   Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
3. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

   Li Tian, Zongzheng Zhao ... Zhaolong Li
4. 1. Immunology and Inflammation

   A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

   Zhiyan Wang, Nore Ojogun ... Mingfang Lu

   A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.
5. 1. Cell Biology
   2. Immunology and Inflammation

   RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

   Alejandro Rosell, Agata Adelajda Krygowska ... Esther Castellano Sanchez

   Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
6. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

   Malika Hale, Kennidy K Takehara ... Marion Pepper

   Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

   Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle
8. 1. Immunology and Inflammation
   2. Stem Cells and Regenerative Medicine

   IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

   Daniel L Aldridge, Zachary Lanzar ... Christopher A Hunter
9. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

   Jan Stuchly, David Novak ... Tomas Kalina
10. 1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

    Douwe Schulte, Marta Šiborová ... Joost Snijder

    Germline V-gene usage can be inferred from cryoEM reconstructions of antigen-antibody complexes to guide de novo antibody sequencing of complex mixtures by mass spectrometry.