David Bolumar, Javier Moncayo-Arlandi ... Felipe Vilella
In vitro analyses reveal how vertical DNA transmission from the mother to the pre-implantation embryo via endometrial extracellular vesicles can impact embryo bioenergetics.
Stereotactic body radiotherapy combined with immunotherapy and chemotherapy in neoadjuvant setting exhibited a promising anti-tumor activity and an acceptable safety profile in triple-negative breast cancer patients.
A comprehensive platform is established for the evaluation of both current and future individuals afflicted with the UBA5-associated developmental and epileptic encephalopathy.
Inhibition of RyR2 hyperactivity with dantrolene not only prevents VT/VF and SCD but also heart failure by mitigating calcium dysfunction in pressure-overloaded hearts.
The ability of the therapeutic glucagon-like peptide-1 receptor agonist liraglutide to promote weight loss is partly dependent on signaling via PKA-dependent phosphorylation of the mTORC1 regulator protein Raptor.
Jeffrey Thompson, Yidi Wang ... Ulrich H von Andrian
A claims-based retrospective cohort study shows that patients who used bisphosphonates between 01/01/2019 and 02/29/2020 had dramatically reduced odds of SARS-CoV-2 testing, COVID-19 diagnosis, and COVID-19-related hospitalizations during the initial surge of the COVID-19 pandemic in the US.
Single-cell combined spatial transcriptomics provides the molecular foundation for investigating how ligamental cell identities, biochemical functions, and interactions contributed to the ligamental degeneration process.
Michaela E Trautman, Leah N Braucher ... Dudley W Lamming
A high-protein diet promotes unfavorable metabolic effects in mice, but resistance exercise training protects from some of these effects while promoting muscle hypertrophy and increased strength.
