Browse our latest Medicine articles

Page 16 of 64
    1. Immunology and Inflammation
    2. Medicine

    Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

    Yufang Ding, Karin Yanagi ... Arul Jayaraman
    A microbiome metabolite alleviates liver steatosis and inflammation, and shows its potential as a therapeutic modality for non-alcoholic fatty liver disease.
    1. Medicine

    Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

    Erika Zodda, Olga Tura-Ceide ... Marta Cascante
    Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
    1. Medicine

    Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

    Shengjie Li, Jun Ren ... Wenjun Cao
    Metabolomic analyses have developed and validated serum androstenedione as a reliable and effective diagnostic and predictive biomarker for primary angle closure glaucoma in clinical routines.
    1. Medicine

    Viral Infections: Race against dengue

    Swee Sen Kwek, Eng Eong Ooi
    Understanding the kinetics of dengue viruses in the bloodstream can provide insights into the clinical outcomes of the disease.
    Version of Record
    Insight
    1. Medicine

    Correlated signatures of social behavior in cerebellum and anterior cingulate cortex

    Sung Won Hur, Karen Safaryan ... Peyman Golshani
    Development of a novel open-source device, 'E-Scope,' to simultaneously record electrophysiology and calcium imaging in freely behaving animals, discovering co-modulation of the cerebellum, and anterior cingulate cortex during social interaction.
    1. Computational and Systems Biology
    2. Medicine

    A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

    Gonzalo Hernandez-Hernandez, Samantha C O'Dwyer ... Colleen E Clancy
    A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.
    1. Medicine
    2. Neuroscience

    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

    Sang-Hyeon Hann, Seon-Yong Kim ... Young-Yun Kong
    Fibro-adipogenic progenitors in skeletal muscle contribute to the neuromuscular pathogenesis of spinal muscular atrophy, and depletion of SMN in chondrocytes reduces local IGF sigaling in growth plate.
    1. Epidemiology and Global Health
    2. Medicine

    Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

    Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
    A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
    1. Immunology and Inflammation
    2. Medicine

    β-Carotene accelerates the resolution of atherosclerosis in mice

    Ivan Pinos, Johana Coronel ... Jaume Amengual
    Vitamin A formation from β-carotene promotes an anti-inflammatory environment and remodeling of atherosclerotic lesions during the healing of atherosclerosis.
    1. Evolutionary Biology
    2. Medicine

    Taste shaped the use of botanical drugs

    Marco Leonti, Joanna Baker ... Julie Hawkins
    Plant drugs used by ancient Graeco-Roman societies have tastes and flavours that predict how they were used therapeutically.