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Melanocortin 1 receptor (MC1-R) deficiency in hepatocytes increases cholesterol levels in the circulation and liver in mice, while selective activation of MC1-R reduces cellular cholesterol content in cultured hepatocytes.

MS-Hu6 biotherapeutic formulation for the treatment of osteoporosis, obesity, and Alzheimer's disease.

Definitions of reproducibility vary considerably across disciplines and overall rates of reproducibility are low irrespective of the definition used.

A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one's genetics and physiology increases its placebo effect on pain.

Enhancing the management of Gaucher disease patients through multidimensional risk assessment serves as a roadmap towards personalized medicine in the context of a rare disease.

The sialylation of RANK⁺TLR2⁺ monocytes contributes to osteoclastogenesis and bone destruction in rheumatoid arthritis.

A subtype of myeloid monocyte mediates the transition from autoimmunity to joint destruction in rheumatoid arthritis.

The synergy between aging and injury impairs alveolar progenitor functions leading to progressive lung fibrosis.

HepG2 transmitochondrial cybrids of haplogroup J genome had increased sensitivity to aspects of mitochondrial dysfunction induced by tolcapone and 2-hydroxyflutamide, compared to haplogroup H, thus cybrids provide a practical system to investigate the consequences of mitochondrial genome on drug-induced hepatotoxicity.

Experimentation on patient biopsies, cell culture, and xenograft models demonstrates involvement of ErbB signaling and fibroblasts in lesion growth, implying that targeting of both stromal and endothelial cells could be a beneficial treatment strategy for patients with venous lesions.