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It may be possible to treat cardiac hypertrophy and injury by using drugs that inhibit a protein called SIRT2.

A common genetic variant in Black patients increases the risk of renal disease, which increases the risk of sepsis, but there is no direct association between the variant and sepsis.

SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, and targeting SIRT2 may provide a novel avenue for the treatment of cardiac hypertrophy and ischemic disease.

Inhibiting triglyceride storage in adipose tissue prevents obesity and improves metabolic health.

Essential advice for trainees when evaluating postgraduate physician scientist training programs.

Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.

Neutrophils are the predominant phagocytes that clear dead liver cells under normal physiological conditions.

Our latest Special Issue brings together research covering many different aspects of the impact of the COVID-19 pandemic on cancer outcomes across the globe.

The balanced utilization of energy sources, namely carbohydrates and fats, by mitochondria, is critically important for the long-term maintenance of both skeletal muscle and heart health.

The new early warning system, COEWS, will improve the early identification and management of high-risk COVID-19 patients compared to the widely used NEWS2 by using easy-to-obtain clinical parameters that have been externally validated in a diverse multicontinental cohort of patients.