An aorta smooth muscle-on-a-chip model indicated that NOTCH1 insufficiency in HAoSMCs induced phenotypic switching from a contractile to a synthetic phenotype accompanied by an impairment of mitochondrial fusion, implying its potential role as a therapeutic target for BAV-TAA.
Elisabeth Gludovacz, Kornelia Schuetzenberger ... Thomas Boehm
Because heparin-binding motif mutations of human diamine oxidase (hDAO) block cellular uptake and strongly decrease clearance in vivo, modified recombinant hDAO might be a good candidate for the treatment of symptoms induced by excessive endogenous histamine release.
Novel human models of the lung and intestine are described and validated as preclinical in vitro tools for predictive profiling of T-cell-bispecific antibodies with expected on-target off-tumor risk.
Steven J Clipman, Shruti H Mehta ... Sunil S Solomon
Beyond well-recognized individual-level risk factors, HIV and hepatitis C transmission among people who inject drugs are further impacted by social and spatial network composition, and spaces in particular may represent efficient means for disseminating interventions that diffuse through the network.
CD44-/CD24- breast cancer cells contribute to delayed postoperative distant metastasis by their spontaneous conversion into CD44+/CD24- breast cancer stem cells (CSCs).
Methadone maintenance treatment (MMT) can alleviate opioid dependence, however, drivers receiving MMT were at high risk of motor vehicle collisions in the present study, particularly the first 90 days of MMT.
NICEdrug.ch is a resource allowing systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity in the context of cellular metabolism.
Disruption of epoxide hydrolysis inducing oxidative stress and cellular senescence is a novel mechanism responsible for lipoatrophic monogenic diabetes.
