Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci
12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
Priya M Christensen, Jonathan Martin ... Kelli L Palmer
A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.
Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch
The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
Clara Bekirian, Isabel Valsecchi ... Thierry Fontaine
β-1,6-Glucan is crucial for Candida albicans cell wall structure and integrity, adapting dynamically to environmental stresses and compensating for mannan deficiencies in cell wall organization.
Knockout of Terc impedes effective immune defense against bacterial lung infections in mice, exacerbating disease course and revealing the critical function of Terc in pulmonary immunity.
A new peptidoglycan hydrolase mined from Acinetobacter baumannii proteome by lysin-derived antimicrobial peptide-primed screening strategy undergoes a unique switch between dimer and monomer after heat treatment and protects mice from A. baumannii infection.
