Flavia A Zanetti, Ignacio Fernandez ... Laura Ruth Delgui
Molecular, biophysical, and computational analysis reveals insights on the mechanism of association of birnavirus VP3 with endosomes and its role in the viral life cycle, representing a substantial contribution toward understanding the replication strategy of these 'non-canonical' viruses.
In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
Newly produced genomic data, as well as available datasets, reveal the pathogen's global transmission history along with the live poultry trade and pinpoint mobile element-driven local Salmonella adaptation.
Attenuation of viral Nef-driven PI3 kinase signaling in B cells precedes the induction of neutralizing antibody responses against a difficult-to-neutralize simian immunodeficiency virus.
AhCobQ, a novel bacterial lysine deacetylase, functions independently of NAD+ and Zn2+, revealing a previously unknown domain and broad implications for metabolic regulation in prokaryotic systems.
A model is proposed to estimate the nuclear export rate of mRNAs produced in a transcription burst, using the spatial distribution of mRNAs determined by single-molecule RNA imaging.
An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
