Browse our latest Microbiology and Infectious Disease articles

Aminoglycoside tolerance in tricarboxylic acid cycle and electron transport chain mutants does not result from impaired proton motive force and altered drug uptake, but rather from the downregulation of ribosomal proteins, which are primary targets of this drug class.

Population-level hybrid immunity depends substantially on vaccination coverage, including among those previously infected, and dried blood spot collection serves as a practicable biological surveillance platform for these immune responses.

X-ray crystallographic and atomic force microscopic analyses reveal the tilted homodimer structure and unanticipated dynamic characteristics of canine distemper virus-hemagglutinin (CDV-H), providing insights into the molecular and dynamic processes of Morbillivirus for cell entry, effective immunizations, and vaccine/drug design.

A novel strategy to combat antimicrobial resistance has been identified by using vaccines and nanobodies to target specific extracellular proteins located on multiresistant bacterial plasmids.

Distinct members of the Caenorhabditis elegans microbiota can have widely divergent effects on Orsay virus transmission, such that associated bacteria can effectively determine host susceptibility versus resistance to viral infection.

Exploration of the target of rapamycin pathway in Aspergillus flavus reveals critical regulatory elements influencing aflatoxin synthesis and stress tolerance, offering potential targets for antifungal strategies.

M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.

A new study reveals how naturally occurring mutations affect the biophysical properties of nucleocapsid proteins in SARS-CoV-2.

Exploration of the phenotype space corresponding to the sequence space of viable SARS-CoV-2 nucleocapsid protein species reveals significant diversity of biophysical characteristics, nonlocal mutation effects, and functional constraints.