Browse our latest Microbiology and Infectious Disease articles

PBP-lipo is an essential cell-wall synthesis enzyme in Mycobacterium abscessus that localizes to the septum and whose expression is required for normal cell growth and division, as well as mediating sensitivity to several antibiotics including the β-lactams, ampicillin, and amoxicillin.

Novel cell-free biochemical experiments show that the host GTPase MxB can restrict the infection of alphaherpesviruses by disassembling the sturdy viral capsids so that they can no longer protect the viral genomes.

A restriction factor induced by interferons blocks the replication of herpesviruses by disassembling the capsid proteins surrounding their genome.

A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.

A newly developed computational framework provides an overview of the extent, diversity, and relevance of the genes of unknown function in genomes and metagenomes.

Membrane homeostasis in bacteria relies on the controlled degradation of endogenous phospholipids by intracellular phospholipases A, however their structures and catalytic mechanism are still poorly understood.

Listeria monocytogenes uses respiration to sustain a risky fermentative lifestyle during infection.

The HIV proteins Env and Rev encode helices that overlap in the viral genome but alternate in functional importance so that the non-functional surface of one helix encodes the functional surface of the other.

Brucella facilitates its intracellular parasitism by hijacking the host-regulated IRE1α-dependent decay (RIDD)-BLOS1 innate immune defense system through the disassembly of the BLOC-1-related complex that results in the perinuclear trafficking of Brucella-containing vacuoles and enhanced susceptibility to infection.

RNAseq profiles of female Aedes body parts, gut regions, and blood-fed guts provide insight into the anatomical patterning of immune and digestive function, and demonstrate the sequential induction of multiple peptidase cohorts over the course of blood meal digestion.