Browse our latest Microbiology and Infectious Disease articles

Page 61 of 173
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

    Ceri Alan Fielding, Pragati Sabberwal ... Richard J Stanton
    SARS-CoV-2 host-shutoff inhibits innate NK surveillance by suppressing activating ligands, however ADCC provides a potent NK stimulus that is mediated by antibodies targeting Nucleocapsid, ORF3a, and Membrane, with those targeting Spike being significantly weaker.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat

    Mengyao Wang, Yu Qi ... Hongbing Han
    The Toll-like receptor 2-4 genetic modification goat improves effectively resistance against Staphylococcus aureus infection by enhancing autophagy level, and it provides a novel strategy for challenge of S. aureus-caused infections.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Natural Killer Cells: Taking on SARS-CoV-2

    Paola Kučan Brlić, Ilija Brizić
    A new study sheds light on how SARS-CoV-2 influences the way natural killer cells can recognize and kill infected cells.
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    Insight
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

    Carlos-Henrique D Barbosa, Fábio B Canto ... Maria Bellio
    Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.
    1. Microbiology and Infectious Disease

    Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant

    Dallas L Mould, Mirjana Stevanovic ... Deborah A Hogan
    Microbial variants that arise during chronic lung infections have an increased ability to use nutrients that are abundant in lung infections.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

    Piotr Kolesinski, Kuei-Chen Wang ... Partho Ghosh
    Streptococcus pyogenes M87 protein unfurls its coiled coil to capture and neutralize the human antimicrobial peptide LL-37.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

    Tracy M Smith, Madison A Youngblom ... Caitlin S Pepperell
    Mycobacterium tuberculosis, which causes tuberculosis, can evolve rapidly in response to new environments by mutating genetic regulators that control multiple genes at once.
    1. Microbiology and Infectious Disease

    Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

    Valérie Laroute, Catherine Beaufrand ... Muriel Cocaign-Bousquet
    Generally recognised as safe GABA-producing L. lactis strains could be considered as future therapeutic agents for the management of visceral pain and the anxious profile of IBS patients.
    1. Microbiology and Infectious Disease

    WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae

    Josué Flores-Kim, Genevieve S Dobihal ... David Z Rudner
    Selective removal of Wall Teichoic Acids from the envelope of Streptococcus pneumoniae prevents bacteriolysis and directs zonal cell wall synthesis.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity

    Isabel Nocedal, Michael T Laub
    Ancestral reconstruction of a signaling pathway reveals the mutations responsible for producing specificity of the two paralogous pathways produced by a duplication event.