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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transition of Staphylococcus aureus tetracycline resistance plasmid pT181 from independent multicopy replicon to predominantly integrated chromosomal element over 65 years

    Megan A Phillips, Robert A Petit ... Timothy D Read
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Neutralizing human monoclonal antibodies that target the PcrV component of the type III secretion system of Pseudomonas aeruginosa act through distinct mechanisms

    Jean-Mathieu Desveaux, Eric Faudry ... Pascal Poignard
    Human antibodies isolated from cystic fibrosis patients against PscF and PcrV of the Pseudomonas aeruginosa Type 3 Secretion System reveal that anti-PcrV antibodies inhibit secretion through distinct mechanisms.
    1. Microbiology and Infectious Disease

    Glycolysis-dependent sulfur metabolism orchestrates morphological plasticity and virulence in fungi

    Dhrumi Shah, Nikita Rewatkar ... Sriram Varahan
    A multidisciplinary approach demonstrates that glycolysis orchestrates fungal morphogenesis and virulence by regulating the de novo biosynthesis of sulfur-containing amino acids, thereby establishing a novel metabolic paradigm.
    1. Microbiology and Infectious Disease

    ZFT is the major iron and zinc transporter in Toxoplasma gondii

    Dana Aghabi, Cecilia Gallego Rubio ... Clare R Harding
    Identification of the mechanism of iron and zinc uptake by Toxoplasma gondii to support parasite replication and metabolism.
    1. Microbiology and Infectious Disease

    High-Throughput Quantification of Population Dynamics using Luminescence

    Malte Muetter, Daniel Angst ... Sebastian Bonhoeffer
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Mast cells promote pathology and susceptibility in tuberculosis

    Ananya Gupta, Vibha Taneja ... Shabaana A Khader
    Conserved mast-cell activation, marked by elevated protease expression, aligns with progressive tuberculosis across human, macaque, and murine models.
    1. Microbiology and Infectious Disease

    Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

    Abigail G Hall, Abdulelah A Alqarzaee ... Vinai C Thomas
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

    Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree
    In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

    Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis
    In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
    1. Microbiology and Infectious Disease

    Stratification of viral shedding patterns in saliva of COVID-19 patients

    Hyeongki Park, Yoshimura Raiki ... Taiga Miyazaki
    Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.
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