Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
In vitro, ex vivo, and in vivo studies reveal that hepatocytes are significantly infected by Mycobacterium tuberculosis which rewires the host cell metabolism to upregulate the lipid biosynthetic pathways.
Reducing vaccine development time from 12 months to 6 reduces forecasting error by 25%, while reducing lags in genome sequence submission reduces uncertainty of current clade frequencies by 50%.
Luz Saavedra-Sanchez, Mary S Dickinson ... Jorn Coers
The enteric bacterial Shigella secretes a virulence factor that degrades the pivotal human defense protein RNF213, thereby protecting cytosolic bacteria from interferon-driven ubiquitylation and associated innate immunity.