Transcriptional regulatory network models can aid in identifying candidate genes associated with the target phenotype in bacterial genome-wide association studies.
Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
The thickness of the periplasmic region is reduced in strains of pneumococcus that are deleted in genes responsible for the incorporation of teichoic acid in the cell envelope.
HSV-ΔICP34.5 reactivates latent HIV by modulating PP1-HSF1 and NF-κB pathways, offering a potential HSV-vectored therapeutic vaccine for a functional cure.
Aleksandra Prochera, Anoohya N Muppirala ... Meenakshi Rao
Genetic depletion of enteric glia in vivo disrupts antimicrobial peptide secretion by Paneth cells to change fecal microbial composition but does not broadly alter other intestinal programs.