A pioneering Bolivian seroepidemiological study employed innovative serological and neutralization assays as highly effective complements to genomic surveillance, delivering critical insights into SARS-CoV-2 variant circulation and informing public health strategies.
Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an immunologic risk factor.
In methicillin-resistant Staphylococcus aureus, evolution of bacteriophage resistance causes trade-offs that re-sensitize the bacteriato β-lactam antibiotics.
A single β-lactam exposure rapidly drives stable multidrug resistance in RecA-deficient bacteria through an SOS-independent mechanism involving oxidative stress-induced mutagenesis and antibiotic-driven selection.
CRP/cAMP plays a crucial role in the metabolic shift of Escherichia coli persisters from an anabolic state to oxidative phosphorylation, which is essential for their survival during antibiotic treatment.
