Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

    Jinfeng Cai, Hongbo Gao ... Kai Deng
    A novel reporter model system serves as a valuable tool for studying latent HIV-1 infection and identifies potent latency reversing agent.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

    Philipp Kolb, Katja Hoffmann ... Hartmut Hengel
    Molecular mechanisms reveal that human cytomegalovirus has evolved to deploy two individual glycoproteins working in synergy to efficiently evade antibody-mediated immunity mediated by Fc-gamma receptors.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

    Deniz Cizmeci, Giuseppe Lofano ... Boris Julg
    Extended somatic hypermutation and clonal evolution associated with antibody neutralization breath in HIV controllers with low plasma viral loads provide promise for HIV vaccine development.
    1. Microbiology and Infectious Disease

    A mobile genetic element increases bacterial host fitness by manipulating development

    Joshua M Jones, Ilana Grinberg ... Alan D Grossman
    A mobile genetic element provides a selective advantage to host cells by delaying development, including biofilm and spore formation, thereby enabling temporary cheating and extra divisions.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integron activity accelerates the evolution of antibiotic resistance

    Célia Souque, José Antonio Escudero, R Craig MacLean
    Integrons deploy a variety of adaptive strategies including excision, shuffling, and duplication of cassettes that foster rapid bacterial adaptation and resistance evolution while protecting the genomic integrity of the host.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Antibiotic Resistance: Bacterial evolution on demand

    Pål J Johnsen, João A Gama, Klaus Harms
    Bacteria carry antibiotic resistant genes on movable sections of DNA that allow them to select the relevant genes on demand.
    Version of Record
    Insight
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage

    Stefanie Deinhardt-Emmer, Daniel Wittschieber ... Gita Mall
    Early postmortem autopsy of COVID-19 patients shows high viral loads and damage of the lung, although extrapulmonary cells demonstrate no injury, they contribute to inflammation, hyper-coagulation, and multiple organ dysfunction.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genomic and healthcare dynamics of nosocomial SARS-CoV-2 transmission

    Jamie M Ellingford, Ryan George ... Graeme CM Black
    Characterisation of SARS-CoV-2 genomic divergence in healthcare-associated outbreaks demonstrates that the inclusion of healthcare workers in contact networks identifies additional links in SARS-CoV-2 transmission pathways.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    PomX, a ParA/MinD ATPase activating protein, is a triple regulator of cell division in Myxococcus xanthus

    Dominik Schumacher, Andrea Harms ... Lotte Søgaard-Andersen
    In the PomX/Y/Z cell division regulatory system, PomX is a PomZ ATPase activating protein, a scaffold for PomX/Y/Z complex formation, and important for fission of the PomX/Y/Z complex during division.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park, Karine Prévost ... Jingyi Fei
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.