Browse our latest Microbiology and Infectious Disease articles

Page 94 of 168
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

    Jeziel Dener Damasceno, Catarina A Marques ... Richard McCulloch
    Duplication of Leishmania chromosomes combines S-phase DNA replication initiated at a single internal region with subtelomeric DNA replication detectable outside S-phase, potentially explaining genome plasticity in this important parasite.
    1. Microbiology and Infectious Disease

    Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

    Michael J Sheedlo, Jeong Min Chung ... D Borden Lacy
    The structure of a Type IV secretion system provides a framework for understanding assembly of a protein-injection machine.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex

    Clarissa L Durie, Michael J Sheedlo ... Melanie D Ohi
    The structure of the Legionella pneumophilaType IV secretion system provides the detailed molecular model of this complex molecular machine required for pathogenesis.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll, Tatsuro Nishikino ... Jun Liu
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Poultry farmer response to disease outbreaks in smallholder farming systems in southern Vietnam

    Alexis Delabouglise, Nguyen Thi Le Thanh ... Maciej F Boni
    Longitudinal monitoring of poultry farms in southern Vietnam reveals that when outbreaks occur with symptoms similar to highly pathogenic avian influenza, farmers respond by sending their chickens to market early.
    1. Microbiology and Infectious Disease

    The Mla pathway in Acinetobacter baumannii has no demonstrable role in anterograde lipid transport

    Matthew J Powers, Brent W Simpson, M Stephen Trent
    An outer membrane vesicle pulse-chase assay demonstrates that the Acinetobacter baumannii Mla system is a retrograde lipid transporter.
    1. Microbiology and Infectious Disease

    Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells

    Pradyot Bhattacharya, Rada Ellegård ... Marie Larsson
    Complement opsonized HIV exposure gives rise to a colorectal mucosal environment with an initial suppressed antiviral response and increased infection of immune cells and altered activation of T cells.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

    Jeannette L Tenthorey, Candice Young ... Harmit S Malik
    Mutations in the TRIM5α retrovirus-binding interface frequently improve but rarely disrupt retroviral restriction.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift, Krithika Rajaram ... Sean T Prigge
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.
    1. Microbiology and Infectious Disease

    The host exosome pathway underpins biogenesis of the human cytomegalovirus virion

    Declan L Turner, Denis V Korneev ... Rommel A Mathias
    The HCMV virion envelope is derived from the host exosome membrane, and exosome machinery and export pathways facilitate virion egress.