Browse our latest Microbiology and Infectious Disease articles

Page 93 of 168
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston, John R Barnes ... Trevor Bedford
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Seasonal Influenza: The challenges of vaccine strain selection

    Amanda C Perofsky, Martha I Nelson
    New measures of influenza virus fitness could improve vaccine strain selection through more accurate forecasts of the evolution of the virus.
    Version of Record
    Insight
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

    Dihia Moussaoui, James P Robblee ... Anne Houdusse
    The structure of full-length myosin A provides some hints about its atypical mechanism, and reveals that the light chain PfELC is a target to block malaria pathogenesis.
    1. Microbiology and Infectious Disease

    Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

    Sebastian Felgner, Matthias Preusse ... Susanne Häussler
    Upon host cell contact, motile but not non-motile Pseudomonas aeruginosa exhibit a change in their gene expression program that includes the expression of spermidine, which triggers motility-dependent phagocytosis.
    1. Microbiology and Infectious Disease

    Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

    Michelle M Lissner, Katherine Cumnock ... David Schneider
    Illustrating the impact of host metabolism on infection outcome, loss of the aryl hydrocarbon receptor in radioresistant cells leads to heme-mediated kidney toxicity during malaria.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship

    Jon C Emery, Timothy W Russell ... Rein MGJ Houben
    Nearly 75% of SARS-CoV-2 infections on the Diamond Princess were asymptomatic, half were never detected, and asymptomatic infections may have contributed substantially to transmission.
    1. Microbiology and Infectious Disease

    Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

    Jason Neidleman, Xiaoyu Luo ... Nadia R Roan
    An in-depth view of the in vivo blood and tissue HIV reservoir is presented highlighting shared phenotypic features between individuals, thus enabling marked ex vivo enrichment of replication-competent latent cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu, Charisse Flerida A Pasaje ... Emily Derbyshire
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels

    Elisa Gómez-Gil, Rebeca Martín-García ... Jose Cansado
    Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

    Jie Zhang, Lihong Song ... Peter Garred
    A systematic set of experiments reveals how properdin specifically directs AP activation independently of primary C3 deposition additionally as an alternative convertase stabilizer, thus revising immune machinery of complement activation.