Browse our latest Microbiology and Infectious Disease articles

Page 95 of 169
    1. Microbiology and Infectious Disease

    Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

    Michelle M Lissner, Katherine Cumnock ... David Schneider
    Illustrating the impact of host metabolism on infection outcome, loss of the aryl hydrocarbon receptor in radioresistant cells leads to heme-mediated kidney toxicity during malaria.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship

    Jon C Emery, Timothy W Russell ... Rein MGJ Houben
    Nearly 75% of SARS-CoV-2 infections on the Diamond Princess were asymptomatic, half were never detected, and asymptomatic infections may have contributed substantially to transmission.
    1. Microbiology and Infectious Disease

    Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir

    Jason Neidleman, Xiaoyu Luo ... Nadia R Roan
    An in-depth view of the in vivo blood and tissue HIV reservoir is presented highlighting shared phenotypic features between individuals, thus enabling marked ex vivo enrichment of replication-competent latent cells.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu, Charisse Flerida A Pasaje ... Emily Derbyshire
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels

    Elisa Gómez-Gil, Rebeca Martín-García ... Jose Cansado
    Microscopic and biochemical analysis show that the stress-activated MAP kinase pathway targets the formin For3 to modulate actomyosin ring integrity in response to environmental cues.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

    Jie Zhang, Lihong Song ... Peter Garred
    A systematic set of experiments reveals how properdin specifically directs AP activation independently of primary C3 deposition additionally as an alternative convertase stabilizer, thus revising immune machinery of complement activation.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication

    Jeziel Dener Damasceno, Catarina A Marques ... Richard McCulloch
    Duplication of Leishmania chromosomes combines S-phase DNA replication initiated at a single internal region with subtelomeric DNA replication detectable outside S-phase, potentially explaining genome plasticity in this important parasite.
    1. Microbiology and Infectious Disease

    Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

    Michael J Sheedlo, Jeong Min Chung ... D Borden Lacy
    The structure of a Type IV secretion system provides a framework for understanding assembly of a protein-injection machine.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex

    Clarissa L Durie, Michael J Sheedlo ... Melanie D Ohi
    The structure of the Legionella pneumophilaType IV secretion system provides the detailed molecular model of this complex molecular machine required for pathogenesis.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll, Tatsuro Nishikino ... Jun Liu
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..