Light signals adjusting the brain's daily clock induce distinct waveform changes in molecular clock gene rhythms at dawn and dusk, and trigger regionally differential clock changes.
Benoît Boulan, Charlotte Ravanello ... Jean-Christophe Deloulme
CRMP4 is a new actor in the guidance cue Semaphorin-3E pathway, crucially involved in the establishment of the fornix, a key axonal tract for memory and emotional control.
NMNAT is genetically required for glioma development and promotes glioma growth by allowing a higher tolerance to DNA damage and inhibiting DNA damage-p53-caspase-3 apoptosis signaling pathway by enhancing NAD+-dependent posttranslational modifications (PTMs) poly(ADP-ribosyl)ation (PARylation) and deacetylation of p53.
Elitsa Stoyanova, Michael Riad ... Nathaniel Heintz
5-Hydroxymethylcytosine-mediated active DNA demethylation occurs in postmitotic neurons, and is required for their terminal differentiation and function.
In vivo recordings from identified cell classes in the olfactory cortex of a novel transgenic mouse reveal that distinct classes of principal neurons operate largely in parallel and differentially process odor information.
Simon M Hofmann, Felix Klotzsche ... Michael Gaebler
Modulations of alpha oscillations from parieto-occipital brain regions can be used to decode subjective emotional arousal in a dynamic naturalistic virtual reality experience.
A novel naturalistic environment with a touchscreen enables high-quality eye tracking for studying visual cognition in monkeys, and allows naive monkeys to learn complex tasks through a combination of social observation of trained monkeys and trial-and-error learning.
Cortical offset responses are not only inherited from the periphery but also amplified and de novo generated, and preventing them decreases the ability to detect sound termination.
Benjamin D Gastfriend, Hideaki Nishihara ... Eric V Shusta
Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.
The traditional herbal medicine Gastrodia elata Blume, in the water-extracted form as food supplement, improves locomotion and protects dopaminergic neurons in Lrrk2-G2019S Parkinson’s disease models through Nrf2 activation in glia.
