Browse our latest Neuroscience articles

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    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau, Devid Damiani ... Fadel Tissir
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Neuroscience

    Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

    Alexander Fengler, Lakshmi N Govindarajan ... Michael J Frank
    A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
    1. Developmental Biology
    2. Neuroscience

    Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

    Matthieu Genestine, Daisy Ambriz ... Edmund Au
    Species-specific timing of interneuron migration across mice and humans is regulated by two vascular-derived factors, SPARC and SerpinE1.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural determinants of voltage-gating properties in calcium channels

    Monica L Fernández-Quintero, Yousra El Ghaleb ... Bernhard E Flucher
    Structure modeling, site-directed mutagenesis, and current recordings revealed the mechanism by which stabilization of voltage sensors in the resting and activated states determines the gating properties of the CaV1.1 calcium channel.
    1. Developmental Biology
    2. Neuroscience

    Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility

    Cassandra B Klune, Benita Jin, Laura A DeNardo
    An analysis of recent literature advances novel hypotheses and suggests new experimental approaches in order to build an integrated understanding of prefrontal neural architecture and behavioral repertoires during development.
    1. Developmental Biology
    2. Neuroscience

    Robo recruitment of the Wave regulatory complex plays an essential and conserved role in midline repulsion

    Karina Chaudhari, Madhavi Gorla ... Greg J Bashaw
    Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
    1. Neuroscience

    Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

    Michael Schaum, Edoardo Pinzuti ... Oliver Tüscher
    Response inhibition is initiated by the right inferior frontal gyrus (rIFG), and stopping performance is predicted by beta-band power as well as beta-band connectivity between rIFG and pre-supplementary motor area.
    1. Neuroscience

    An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

    Bo-yong Park, Richard AI Bethlehem ... Boris C Bernhardt
    Manifold learning of longitudinal brain network data provides novel insights into adolescent structural connectome maturation, and how multiple scales of cortical and subcortical organization interact in typical neurodevelopment.
    1. Medicine
    2. Neuroscience

    Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials

    Maria M Cobo, Caroline Hartley ... Rebeccah Slater
    Measuring individual differences in noxious-evoked baseline sensitivity in neonates can substantially reduce sample sizes required in neonatal analgesic trials.
    1. Medicine
    2. Neuroscience

    AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa

    Yunlu Xue, Sean K Wang ... Constance L Cepko
    AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.