A broadly applicable method that faithfully preserves genetically labeled cellular structures for 3D electron microscopy (EM) and correlated light and electron microscopy (CLEM).
Azadeh Yazdan-Shahmorad, Daniel B Silversmith ... Philip N Sabes
Focal optogenetic stimulation strengthens functional connectivity between primary somatosensory and motor cortices in macaques, in a manner consistent with a Hebbian model of stimulus-driven plasticity.
Rogier B Mars, Stamatios N Sotiropoulos ... Saad Jbabdi
White matter connectivity assessed using diffusion MRI allows one to compare whole-brain organization between different animal species in a quantitative fashion, identifying homologous areas and regions of unique specialization.
Kevin F Chau, Morgan L Shannon ... Maria K Lehtinen
Unbiased transcriptome analyses reveal that neural progenitor cells downregulate protein biosynthetic machinery during early forebrain development, and this fundamental process matches proteomic changes in the adjacent cerebrospinal fluid and is regulated in part by MYC.
Ali Farshchian, Alessandra Sciutti ... Ferdinando A Mussa-Ivaldi
The brain obtains and preserves a consistent temporal alignment of multisensory and motor information flowing along staggered streams by maintaining an invariant estimate across modalities of the energy exchanged with the environment at discrete events.
A combined approach of unbiased proteomics, biochemistry, genetics, and transgenic animal models reveals that GPR56/ADGRG1 regulates myelin formation and repair by interacting with its microglial-derived ligand transglutaminase 2.
Maria M Diehl, Christian Bravo-Rivera ... Gregory J Quirk
Avoiding danger requires inhibitory signaling in the prelimbic prefrontal cortex, as evidenced by optogenetic manipulations based on neuronal firing patterns.
A combination of human imaging and brain stimulation techniques show that the somatosensory cortex is essential to prosocial decision making, by transforming observed pain in accurate perception of others' distress.
Nadine Dijkstra, Pim Mostert ... Marcel AJ van Gerven
In contrast to perception, during visual imagery, there are no clear time-locked processing stages and imagery specifically overlaps with perceptual processing around 160 ms after stimulus onset and from 300 ms onwards.
