Sara González-Rodríguez, Mohiuddin A Quadir ... Christoph Stein
A novel opioid formulation producing analgesia similar to conventional opioids without permeation of blood-brain or intestinal barriers, thus precluding sedation, constipation and respiratory depression.
Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.
Zachary A Knecht, Ana F Silbering ... Paul A Garrity
The neurons and receptors mediating moist air detection in Drosophila are identified, revealing that moist and dry air detection depend on overlapping Ionotropic Receptors and that these pathways are both critical for hygrosensation.
The inhibition mechanism of fear extinction operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that.
A retinotopic proto-organization present at birth provides the infrastructure for the subsequent development of visual cortex that commences at the onset of visual experience.
James A Daniel, Benjamin H Cooper ... Marilyn Tirard
Analyses using His6-HA-SUMO1 and SUMO1 KO mice indicate that SUMO1 modification of synaptic proteins is either absent or cannot be detected in brain and cultured neurons.
Sonal Nagarkar-Jaiswal, Sathiya N Manivannan ... Hugo J Bellen
A conditional gene inactivation system that permits the tracking of protein expression, and creates fluorescently-labelled mutant cells in both developing and adult Drosophila tissues.