Browse our latest Neuroscience articles

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    1. Neuroscience

    Oxytocin signaling in the medial amygdala is required for sex discrimination of social cues

    Shenqin Yao, Joseph Bergan ... Catherine Dulac
    Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.
    1. Neuroscience

    Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses

    Bernard Bloem, Rafiq Huda ... Ann M Graybiel
    Simultaneous 2-photon imaging of striosomes and matrix in mice shows that striosomes preferentially encode reward-predicting cues whereas both striatal compartments demonstrate reward-related activity.
    1. Neuroscience

    Neural activity in cortico-basal ganglia circuits of juvenile songbirds encodes performance during goal-directed learning

    Jennifer M Achiro, John Shen, Sarah W Bottjer
    Activity in cortico-basal ganglia circuits of juvenile songbirds reflects evaluative signals necessary for comparing self-generated behavior to a goal representation during skill learning.
    1. Neuroscience

    Combining robotic training and inactivation of the healthy hemisphere restores pre-stroke motor patterns in mice

    Cristina Spalletti, Claudia Alia ... Matteo Caleo
    A combined rehabitative protocol after stroke in the mouse normalizes transcallosal inhibition and promotes "true recovery" of forelimb motor function.
    1. Neuroscience

    Mouse color and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

    Daniel J Denman, Jennifer A Luviano ... R Clay Reid
    Mice can detect changes in hue independent of luminance, with differing sensitivity to hue and luminance in different parts of visual space.
    1. Neuroscience

    Cortical response states for enhanced sensory discrimination

    Diego A Gutnisky, Charles Beaman ... Valentin Dragoi
    Enhanced perceptual discrimination occurs when ongoing population activity in visual cortex is in a 'silent' mode in which neurons optimize information extraction.
    1. Neuroscience

    Dynamic modulation of activity in cerebellar nuclei neurons during pavlovian eyeblink conditioning in mice

    Michiel M ten Brinke, Shane A Heiney ... Chris I De Zeeuw
    Conditioned olivocerebellar network activity elicits transient spike pauses and timed spike facilitation in the neurons of interposed nuclei that predicts and likely causes conditioned eyelid responses on a trial-by-trial basis.
    1. Neuroscience

    Associability-modulated loss learning is increased in posttraumatic stress disorder

    Vanessa M Brown, Lusha Zhu ... Pearl H Chiu
    Veterans with PTSD show increased attention to a history of unexpected outcomes during loss learning, both as measured by computational model-derived behavioral parameters and in increased neural signaling in amygdala and insula.
    1. Neuroscience

    Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs

    Sébastien Houy, Alexander J Groffen ... Jakob Balslev Sørensen
    Doc2B functions in two distinct vesicle priming steps; membrane localization occludes upstream Ca2+-dependent priming, whereas Ca2+-binding and interaction with synaptotagmin-1, SNAREs, and Munc13-2 are involved in downstream priming, which makes vesicles readily releasable.
    1. Neuroscience

    LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

    Jing-Ping Lin, Yevgeniya A Mironova ... Roman J Giger
    In oligodendrocyte progenitor cells, lipid metabolism and peroxisome biogenesis are regulated by the low-density lipoprotein related-receptor-1, and if disrupted, impair proper white matter development and adult repair.