Differentiation of human pluripotent stem cells mutant for one GATA6 gene can model developmental heart defects seen in some patients with congenital heart disease.
The cytological mechanism of conjugated linoleic acids regulates fat infiltration in skeletal muscles based on pig models via using single-nucleus transcriptomics.
Olivia B Taylor, Nicholas DeGroff ... Andy J Fischer
Inflammatory S1P signaling is dynamically regulated in chick Müller glia after retinal injury and suppresses Müller glia reprogramming into neuron-like cells.
Alison G Barber, Cynthia M Quintero ... Tannishtha Reya
The stem cell signal Msi2 plays a dual role in lung cancer, acting as a signal that is not only essential for initiation, but also for propagation of the tumor.
A non-apoptotic function of the caspase Dronc is essential to promote tissue repair in response to necrosis via a previously uncharacterized mechanism.
It is safe to transplant autologous P63+ progenitor cells isolated from healthy bronchi to IPF patients for the treatment of IPF, and preliminary efficacy has been demonstrated in some patients.
Ana Catarina Costa, Blanca R Murillo ... Monica M Sousa
Proteomic analyses reveal a distinct protein signature underlying microtubule organization and regenerative asymmetries in sensory neuron axons, supported by an in vitro system replicating key features of sensory neuron biology.
Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.
IL-6 signaling drives fibroblast activation in tendinopathy, emerging as a promising therapeutic target for these increasingly prevalent and costly tendon conditions.
