Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Live imaging reveals the progenitors and cell dynamics of limb regeneration

    Frederike Alwes, Camille Enjolras, Michalis Averof
    Long-term live imaging reveals the dynamic cell behaviors and progenitor cells that underpin the regeneration of adult limbs in the crustacean Parhyale hawaiensis.
    1. Stem Cells and Regenerative Medicine

    Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency

    Sheryl Southard, Ju-Ryoung Kim ... Christoph Lepper
    For skeletal muscle in mice, the size of the stem cell pool can be uncoupled from overall tissue size allowing for a dramatic increase in stem cell number.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth, Jurriaan J Hölzenspies ... Joshua M Brickman
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
    1. Stem Cells and Regenerative Medicine
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith, John L Brubacher, Phillip A Newmark
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

    Chintan K Kikani, Xiaoying Wu ... Jared Rutter
    PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    An integrative transcriptomic atlas of organogenesis in human embryos

    Dave T Gerrard, Andrew A Berry ... Neil A Hanley
    Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptomics: How to build a human

    Carla B Mellough, Majlinda Lako
    Version of Record
    Insight
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38

    Christopher P Arnold, M Shane Merryman ... Alejandro Sánchez Alvarado
    An innate immune system signaling pathway in planarians has a dual role: it enhances apoptosis during bacterial infection, but represses apoptosis during tissue regeneration in the absence of infection.