Browse our latest Stem Cells and Regenerative Medicine articles

Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.

A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.

PASK phosphorylates Wdr5 to trigger epigenetic changes at lineage specifying promoters resulting in transcriptional derepression and differentiation of stem or progenitor cells.

Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.

An innate immune system signaling pathway in planarians has a dual role: it enhances apoptosis during bacterial infection, but represses apoptosis during tissue regeneration in the absence of infection.

A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.

The concepts that oxidative muscle fibres cannot be large and that satellite cell number is the major determinant for effective regeneration are fundamentally challenged.

The transcription factor PROP1 controls a genetic network that drives pituitary stem cells to undergo an epithelial-to-mesenchymal-like transition and differentiate.

A newly discovered feedback amplification loop between stem cells and their immediate daughter progenitor cells drives epithelial regeneration and tumor development.