Browse our latest Structural Biology and Molecular Biophysics articles

Page 117 of 177
    1. Structural Biology and Molecular Biophysics

    Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C

    Krishna Chinthalapudi, Sarah M Heissler ... Dietmar J Manstein
    R788 is part of an allosteric communication pathway that connects the converter at the distal end of the myosin motor domain via the relay helix with switch-2 of the active site.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of proton translocation and force generation in mitochondrial ATP synthase

    Niklas Klusch, Bonnie J Murphy ... Werner Kühlbrandt
    Cryo-EM reveals atomic details of two membrane half-channels for translocation of protons that drive rotary catalysis in ATP synthase.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Cell-accurate optical mapping across the entire developing heart

    Michael Weber, Nico Scherf ... Jan Huisken
    The combination of high-speed light sheet microscopy and suitable data analysis facilitates cell-accurate measurements across entire organs and opens the way to systematic, scale-bridging, in vivo studies of organogenesis.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

    Edoardo D'Imprima, Ralf Salzer ... Beate Averhoff
    The pilus extrusion/DNA uptake system of Thermus thermophilus contains a 13-mer of the 757-residue PilQ protein and a tightly bound protein outside the outer membrane with a role in DNA binding.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Computationally-driven identification of antibody epitopes

    Casey K Hua, Albert T Gacerez ... Chris Bailey-Kellogg
    The combination of computational modeling and protein design can reveal key determinants of antibody–antigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.
    1. Structural Biology and Molecular Biophysics
    2. Cancer Biology

    A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression

    Elliot C Woods, FuiBoon Kai ... Carolyn R Bertozzi
    Mucins, long associated with cancer aggression, remodel the cancer glycocalyx in a way that promotes proliferation in the metastatic site by enhancing integrin-mediated adhesion and thus driving cell cycle progression.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

    Gengjing Zhao, Emma S Gleave, Meindert Hugo Lamers
    Competing DNA polymerases at the DNA sliding clamp are revealed by single-molecule co-localization studies.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

    Gemma LM Fisher, César L Pastrana ... Mark S Dillingham
    A combination of structural, biochemical, single-molecule and in vivo methods are used to show how ParB locally condenses the bacterial chromosome near the origin and earmarks this region for segregation.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The mechanism of variability in transcription start site selection

    Libing Yu, Jared T Winkelman ... Richard H Ebright
    Variability in bacterial transcription start site selection involves DNA “scrunching” and “anti-scrunching,” which may represent a general mechanism for start site selection in all organisms.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

    Paul Yourik, Colin Echeverría Aitken ... Jon R Lorsch
    Eukaryotic translation initiation factor 4A is stimulated by the ribosomal pre-initiation complex and promotes the recruitment of mRNAs regardless of their degree of structure.