Browse our latest Structural Biology and Molecular Biophysics articles

Page 118 of 177
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The structure of the COPI coat determined within the cell

    Yury S Bykov, Miroslava Schaffer ... John AG Briggs
    Cryo-electron tomography of COPI vesicles in the Golgi reveals coat structure, disassembly dynamics, cargo binding, and morphological variability.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid

    Ximena Steinberg, Marina A Kasimova ... Sebastian E Brauchi
    Single-molecule measurement of conformational dynamics using a genetically encoded fluorescent probe suggests that the selectivity filter region of TRPV1 channels undergoes dynamic motion during agonist activation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Vesicles: Looking inside the cell

    Eric C Arakel, Blanche Schwappach
    Advances in imaging techniques have shed new light on the structure of vesicles formed by COPI protein complexes.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The gating cycle of a K+ channel at atomic resolution

    Luis G Cuello, D Marien Cortes, Eduardo Perozo
    X-ray crystallographic studies have completed the first atomic resolution description of the kinetic cycle of a potassium channel's pore domain.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate

    Diana C Rodriguez Camargo, Kyle J Korshavn ... Ayyalusamy Ramamoorthy
    The ability of lipid nanodiscs to trap different types of amyloid intermediates, as successfully demonstrated in this study for human-IAPP, could become one of the most powerful approaches to dissect the complicated misfolding pathways of protein aggregation.
    1. Structural Biology and Molecular Biophysics

    The liquid structure of elastin

    Sarah Rauscher, Régis Pomès
    Molecular simulations show how hydrophobicity and conformational disorder underlie the phase separation of elastin-like peptides and the elasticity of human tissues.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An unfolded protein-induced conformational switch activates mammalian IRE1

    G Elif Karagöz, Diego Acosta-Alvear ... Peter Walter
    ER-stress sensing mechanism of the unfolded protein response sensor/transducer IRE1 is conserved from yeast to mammals, where in mammals, unfolded protein binding to IRE1's ER lumenal domain is coupled to its oligomerization and activation through an allosteric conformational change.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates

    Andrew F Mead, Nerea Osinalde ... Coen PH Elemans
    Vertebrate superfast muscles employ similar excitation–contraction strategies but distinct myosin heavy chain genes to allow superfast performance, revealing a maximum speed that cannot be overcome without sacrificing neural control.
    1. Structural Biology and Molecular Biophysics

    Genetically tunable frustration controls allostery in an intrinsically disordered transcription factor

    Jing Li, Jordan T White ... Vincent J Hilser
    Allostery in an intrinsically disordered domain of glucocorticoid receptor is mediated by opposing thermodynamic signals that are directed through the production of different isoforms.
    1. Structural Biology and Molecular Biophysics

    Protein Dynamics: Proteins acting out of (dis)order

    David Eliezer
    A disordered region at the N-terminus of the glucocorticoid receptor can fine tune how cells respond to a hormone via an allosteric mechanism.
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