Browse our latest Structural Biology and Molecular Biophysics articles

Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.

Cryo-EM structures reveal the structural dynamics of ArfA*RF2-mediated rescue of stalled ribosomes.

Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.

B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases.

In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.

Structure of a pathogen effector complexed to Sorting Nexin 5 reveals an evolutionarily conserved interface that is required for retromer-dependent host restriction.

A new component, CatSper zeta, is required for continuous alignment of the calcium channel along the sperm's tail and is crucial for normal sperm swimming behavior and fertility.

A step of contact establishment preceding stable membrane attachment by palmitoylation is identified.

Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.

Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.