Browse our latest Structural Biology and Molecular Biophysics articles

Microbial genetics and biophysical analyses provide insight into an evolutionarily conserved bile salt receptor complex used by pathogenic bacteria to sense their environment.

A combination of an in vitro mitochondrial fusion assay with electron cryo-tomography (cryo-ET) reveals distinct steps and protein complexes during mitofusin-dependent fusion between adjacent mitochondrial outer membranes.

Complexin can have two conformations when bound to a ternary SNARE complex, one of which induces a conformational change of the SNARE complex at the C-terminus.

Munc13 C-terminal domains synergize to coordinate synaptic vesicle docking, priming and fusion.

Outward calcium ion currents desensitize the human PKD2-L1 ion channel via a mechanism that is independent of cytosolic motifs.

Single molecule experiments reveal competition between spliceosome activation and the discard of the triple small nuclear ribonucleoprotein complex.

Structural and biochemical analyses of a eukaryotic DNA transpososome in the integration step reveal how mariner/Tc1 transposons are selectively integrated into a TA target sequence.

PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.

Loop extrusion can robustly compact, segregate and disentangle mammalian chromosomes, suggesting it is a universal mechanism of genome folding during cell division.

Vanilloid sensitivity has been introduced into the TRPV2 channel, revealing that the gating and permeation properties of this enigmatic TRP channel are remarkably similar to the capsaicin receptor.