Browse our latest Structural Biology and Molecular Biophysics articles

Determining how GIRK2 activity depends on the concentration of Gβγ subunits in lipid membranes at different Na⁺ concentrations has allowed the Gβγ concentration generated during GABA_B activation in neurons to be estimated.

The GIRK1 subunit contains a defective Na⁺-binding site but behaves as if it is permanently bound to a sodium ion, and therefore increases the affinity of Gβγ to GIRK1/4 hetero-tetrameric channels in lipid membranes.

A Internal Ribosomal Entry Site RNA has been visualised by high resolution cryoEM, trapped in the ribosome in an intermediate state of translocation.

Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.

A single missense mutation in an RNA recognition motif within a nucleolar protein disrupts ribosome assembly and contributes to human pathology.

p63 uses an intricate network of domain-domain interactions to control its function in long-term quality maintenance of resting oocytes.

The Volta phase plate enables in-focus single particle analysis at near atomic resolutions, which could expand the capabilities of cryo-EM, especially for small, flexible or heterogeneous macromolecular samples.