CaV1.3 channels of the short isoform are coupled via their C-terminal domains in a Ca2+-CaM-dependent manner, which facilitates Ca2+ influx and increases the discharge of hippocampal neurons.
Weiwei Wang, Kouki K Touhara ... Roderick MacKinnon
Determining how GIRK2 activity depends on the concentration of Gβγ subunits in lipid membranes at different Na+ concentrations has allowed the Gβγ concentration generated during GABAB activation in neurons to be estimated.
The GIRK1 subunit contains a defective Na+-binding site but behaves as if it is permanently bound to a sodium ion, and therefore increases the affinity of Gβγ to GIRK1/4 hetero-tetrameric channels in lipid membranes.
Moitrayee Bhattacharyya, Margaret M Stratton ... John Kuriyan
Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.