Browse our latest Structural Biology and Molecular Biophysics articles

Page 165 of 186
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Single-fluorophore membrane transport activity sensors with dual-emission read-out

    Cindy Ast, Roberto De Michele ... Wolf B Frommer
    Building on previous work (De Michele et al., 2013), we report the development of dual-emission AmTrac sensors for in vivo analysis of transporter activity.
    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    The structure of plant photosystem I super-complex at 2.8 Å resolution

    Yuval Mazor, Anna Borovikova, Nathan Nelson
    The crystal structure of higher plant PSI-LHCI complex reveals intricate details responsible for light harvesting.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

    Nicolas Aznar, Krishna K Midde ... Pradipta Ghosh
    Daple is a guanine nucleotide-exchange factor (GEF) for trimeric G proteins that enables Wnt/Frizzled receptors to transactivate G proteins during non-canonical Wnt signaling.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Identification of a lipid scrambling domain in ANO6/TMEM16F

    Kuai Yu, Jarred M Whitlock ... H Criss Hartzell
    The amino acids that are necessary for phospholipid scrambling by ANO6/TMEM16F can, via domain swapping, confer scrambling activity to the chloride ion channel ANO1 that normally does not scramble phospholipids.
    1. Structural Biology and Molecular Biophysics

    Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

    Ashok Sekhar, Jessica AO Rumfeldt ... Lewis E Kay
    Solution NMR spectroscopy reveals the energy landscape of immature Cu, Zn-superoxide dismutase and leads to atomic resolution structural models of transiently populated non-native oligomers.
    1. Structural Biology and Molecular Biophysics

    Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

    Timothy Grant, Nikolaus Grigorieff
    The resolution of electron cryo-microscopy can be improved by using optimal exposure values to filter video frames.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation

    Kacper B Rogala, Nicola J Dynes ... Ioannis Vakonakis
    SAS-5 forms oligomers, through a trimeric coiled coil and novel dimeric domain, that are necessary for centriolar localisation of SAS-5 and for centriole duplication.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

    Matthew A Cottee, Nadine Muschalik ... Susan M Lea
    The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural evidence for Scc4-dependent localization of cohesin loading

    Stephen M Hinshaw, Vasso Makrantoni ... Stephen C Harrison
    Cohesin loading at centromeres depends on a conserved surface cluster of amino-acid residues on the cohesin loading protein, Scc4.