Browse our latest Structural Biology and Molecular Biophysics articles

Single-particle imaging of RSC and ISW2 chromatin remodelers on DNA stretched between dual optical tweezers reveals distinctive 1D diffusion and opposing push–pull nucleosome translocation on engagement with sparse nucleosome arrays.

To find nucleosomes, chromatin remodelers slide and hop along DNA, and their direction of approach affects the direction that nucleosomes slide in.

A multidisciplinary study reveals the reaction mechanism and transition state of adenosine-N⁶ methyl transfer catalyzed by human METTL3-14, deepening our insight into RNA methyltransferases and paving the way for similar studies on related enzymes.

Simulations reveal where phosphoinositide lipids bind to voltage-gated sodium channels and how they reduce channel activity.

Mutation E334Q in cytoskeletal γ-actin leads to impaired interaction of actin filaments with actin-binding proteins belonging to the myosin and ADF/cofilin families.

CryoEM reveals the structure of a two-component archaeal S-layer, which sheds new light on archaeal cell biology.

The dynamics of Sirtuin 6 binding to the nucleosome shed light on how it is able to deacetylate histone H3 lysines close to the core, including K27.

The surface layer of Sulfolobus acidocaldarius consists of a flexible but stable outer protein layer that interacts with an inner, membrane-bound protein.

The use of a conformation-selective inhibitory nanobody provides critical information on MelB at a low-sugar affinity inward-facing Na⁺-bound state for establishing the mobile barrier and substrate-releasing mechanisms.

Histone, PCNA, and DNA binding are essential for CAF-1 functions in preventing DNA damage during DNA replication in Schizosaccharomyces pombe, while its C-terminal domain specifies distinct cellular processes.