Browse our latest Structural Biology and Molecular Biophysics articles

Page 73 of 177
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2

    Chongyuan Wang, Agata Jacewicz ... Stephen Barstow Long
    Cryo-EM structures reveal that MICU1-MICU2 operates like a regulatable toxin to block the pore of the mitochondrial calcium uniporter and confer Ca2+-dependent control.
    1. Structural Biology and Molecular Biophysics

    Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

    Katherine E Huffer, Antoniya A Aleksandrova ... Kenton J Swartz
    Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations

    Jing Xue, Tian Xie ... Xiao-chen Bai
    Cryo-EM analysis of human ZnT8 reveals a large conformational change of TMD during the transport cycle.
    1. Structural Biology and Molecular Biophysics

    Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

    Tone Bengtsen, Viktor L Holm ... Kresten Lindorff-Larsen
    Molecular simulations, small-angle X-ray and neutron scattering experiments and previously measured NMR experiments were combined to study the structure and dynamics of the proteins and lipids in a nanodisc.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Structural Biology and Molecular Biophysics

    Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

    Sigrid Noreng, Richard Posert ... Isabelle Baconguis
    The in-depth structural and functional work provide a deeper understanding as to how the epithelial sodium channel is a heteromeric ion channel that is regulated by Na+ and proteolysis.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

    Charlotte F Kelley, Thomas Litschel ... Naoko Mizuno
    In vitro reconstitution of the core focal adhesion proteins talin and vinculin with actin reveals lipid-dependent release of autoinhibition.
    1. Structural Biology and Molecular Biophysics

    Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme

    Samuel Thompson, Yang Zhang ... Tanja Kortemme
    Changes to cellular protein homeostasis reveal widespread advantageous effects of destabilizing mutations, opening the possibility to switch mutational landscapes back-and-forth from permissive to restrictive.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci, Tiantian Zheng ... Edward A Lemke
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Structural Biology and Molecular Biophysics

    Aromatic interactions with membrane modulate human BK channel activation

    Mahdieh Yazdani, Guohui Zhang ... Jianhan Chen
    Computation and experiment together demonstrate that nonspecific membrane–protein interactions could regulate transmembrane protein function and suggest that covalent linkers can be an integral component of the sensing apparatus.