Gene dosage imbalance due to the triplication of human chromosome 21 gene orthologs impairs whole-body glucose and lipid metabolism by disrupting homeostatic processes across major metabolic tissues.
Jeevan Tewari, Benjamin W Dahl ... Jeffrey J Saucerman
Current general-purpose large language models generate signaling and metabolic networks with only modest accuracy relative to manually curated network models.
Hanane Hadj-Moussa, Megan Ulusan ... Jonathan Houseley
Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.
Hidden outward-facing intermediates and long-lived ATP-bound states reveal how ATP binding drives conformational dynamics in the heterodimeric ABC transporter TmrAB.
Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
Despite the variation in venom across the Bothrops snake genus, repurposed drugs demonstrated pan-species neutralisation in enzymatic, coagulation, and haemorrhage assays, highlighting their value as novel therapies for Neotropical snakebites.
