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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

    Jessica Jocher, Philipp Janssen ... Ines Hellmann
    Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.
    1. Developmental Biology

    Permissive and instructive Hox codes govern limb positioning

    Yajun Wang, Maik Hintze ... Ruijin Huang
    Elucidation of the Hox code defining forelimb positioning provides novel insights into lateral plate mesoderm patterning and the integration of vertebrate column structure and limb positioning.
    1. Immunology and Inflammation

    Integrated single cell multiomic profiling and functional validation reveal distinct cellular routes to human plasma cell differentiation

    Colin A Fields, James F Read ... Deepta Bhattacharya
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    A multi-resolution imaging and analysis pipeline for comparative circuit reconstruction in insects

    Valentin Gillet, Marcel E Sayre ... Stanley Heinze
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Neuroscience

    Drowning a frog respiratory rhythm generator in a wash of excitation: State-dependent architecture of a ventilatory oscillator

    Mufaddal I Baghdadwala, Marina R Sartori, Richard. JA Wilson
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    • Convincing
    1. Neuroscience

    The Periaqueductal Gray Selectively Supports Reversal Learning During a Flexible Discrimination Task in Mice

    Daniela Lichtman, Eyal Bergmann ... Itamar Kahn
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function

    Longxin Xie, Jessica Merjane ... Christopher J Donnelly
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Neuroscience

    Hierarchical cortical plasticity in congenital sight impairment

    Roni O Maimon-Mor, Mahtab Farahbakhsh ... Tessa M Dekker
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modification.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations

    Lucas Inchausti, Lucia Bilbao ... Pablo Smircich
    Transcriptomic heterogeneity in infective-stage surface proteins of Trypanosoma cruzi, particularly trans-sialidase-like superfamily members, suggests distinct expression profiles among individual parasites that may enhance immune evasion and infection adaptability.
    Version of Record
    Short Report
    • Important
    • Convincing
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