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    1. Neuroscience

    Profiling presynaptic scaffolds using split-GFP reconstitution reveals cell-type-specific spatial configurations in the fly brain

    Hongyang Wu, Yoh Maekawa ... Hiromu Tanimoto
    Profiling endogenous Bruchpilot proteins in multiple cell types in mushroom bodies uncovered multilayered spatial configurations of active zones, from stereotyped intracellular distribution patterns to local arrangements of neighboring synapses.
    1. Neuroscience

    Formation of task representations and replay in mouse medial prefrontal cortex

    Hamed Shabani, Hannah Muysers ... Christian Leibold
    Longitudinal calcium imaging in the medial prefrontal cortex reveals the emergence of de novo task representations and reward-associated replay.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dynamic RNA Polymerase compartments organize the transcription of gene clusters

    Yi-Hui Wang, Hannah L Hertz, Wen Tang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Plant Biology

    Alternative splicing of PIF4 regulates plant development under heat stress

    María Niño-González, Benjamin Alary ... Guiomar Martín
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Evolutionary Biology

    No evidence for disassortative mating based on HLA in a small-scale, endogamous population

    Gillian L Meeks, Brooke Scelza ... Brenna M Henn
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    ARID5B mutations cause a neurodevelopmental syndrome with neuroinflammation episodes

    Hendrikus J van Heesbeen, Nazim Rabouhi ... Philippe M Campeau
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

    Sen-Lin Lai, Chris Q Doe
    Fd4 is expressed in NB7-1 and new-born progeny where it activates terminal selector genes to produce lineage-specific neurons.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

    Philip MM Ruppert, Aylin S Gueller ... Jan-Wilhelm Kornfeld
    Transcriptomic profiling on liver and adipose depots reveals tissue-specific and beige-fat–convergent responses to methionine restriction and cold, providing a high-quality resource to guide combinatorial lifestyle interventions for metabolic disease research.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration in human cancer cells

    Ravi Kumar, Simon Couly ... Ashish Lal
    Global proteomics and functional analyses reveal that p53-induced ZMAT3 suppresses mitochondrial respiration by inhibiting transcription of a hexokinase, uncovering a role for ZMAT3 in transcription.
    1. Neuroscience
    2. Computational and Systems Biology

    High performance sorting of motor unit action potentials with EMUsort

    Sean O’Connell, Jonathan A Michaels ... Chethan Pandarinath
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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