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    1. Computational and Systems Biology
    2. Neuroscience

    Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    Aske Ejdrup, Jakob Kisbye Dreyer ... Ulrik Gether
    A computational model of the striatal dopamine system predicts transporter expression and organisation as key determinants of regional striatal dopamine dynamics and distinct signal decoding by D1 and D2 receptors.
    1. Cancer Biology
    2. Physics of Living Systems

    Robust assessment of asymmetric division in colon cancer cells

    Domenico Caudo, Chiara Giannattasio ... Mattia Miotto
    Combining statistical modeling with flow cytometry enables reliable, high-throughput quantification of division asymmetry in live cells, revealing how partitioning noise may shape tumor cell heterogeneity.
    1. Cell Biology

    A single-cell atlas of the testicular interstitium defines Leydig progenitor networks sustaining Leydig cell homeostasis across the lifespan

    Xiaojia Huang, Kai Xia ... Wei Zhao
    Single-cell transcriptomic analysis of the murine testicular interstitium across the lifespan reveals Cd34+/Sox4+ mesenchymal cells as Leydig progenitors, whose aging-associated decline in glutathione and Sox4-regulated regenerative capacity inform potential therapeutic strategies for age-related testicular dysfunction.
    1. Neuroscience

    Domain-adaptive matching bridges synthetic and in vivo neural dynamics for neural circuit connectivity inference

    Kaiwen Sheng, Shanghang Zhang ... Kai Du
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Synaptic Encoding of Time in Working Memory

    Gianluigi Mongillo, Misha Tsodyks
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    Feedback of peripheral saccade targets to early foveal cortex

    Luca Kämmer, Lisa M Kroell ... Martin N Hebart
    Low-level features of peripheral saccade targets are fed back to early foveal retinotopic cortex in a signal that resembles activation elicited by direct foveal presentation.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation

    Mahmud Arif Pavel, Hanna Chen ... Dawood Darbar
    Genetic and electrophysiological studies uncover a mechanism linking a TTN missense variant to atrial fibrillation by coupling titin with potassium channel remodeling, revealing FHL2 as a modulator and therapeutic target.
    1. Developmental Biology

    Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

    Ioakeim Ampartzidis, Elliott M Thompson ... Gabriel L Galea
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Human spinal cord organoids reveal cell intercalation as a conserved mechanism for secondary neurulation

    José Blanco-Ameijeiras, Yara El Majzoub ... Elisa Martí
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Immunology and Inflammation

    Western lifestyle linked to maladaptive trained immunity

    Aurelia Josephine Merbecks, Christabel Mennicken ... Eicke Latz
    Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
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