Marilina Raices, Fabiola Balmir ... Judith L Yanowitz
HIM-5 emerges as a central scaffold that coordinates SPO-11 accessory complexes to control different aspects of meiotic DNA double-strand breaks, ensuring robust crossover formation on autosomes and the X chromosome.
Independent experimental approaches demonstrate changes in TFAM binding to UVC-irradiated DNA, providing a potential mechanism for DNA damage sensing in the mitochondria.
A DNA origami nanospring introduces a force-sensing technology that enables measurement of motor protein stall forces without optical trapping, detecting force changes in kinesin KIF1A and its disease-related mutants.