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    1. Neuroscience

    Pupil dilation offers a time-window on prediction error

    Olympia Colizoli, Tessa M van Leeuwen ... Harold Bekkering
    Pupil dilation provides a physiological readout of information gain during the brain's internal process of belief updating in the context of associative learning.
    1. Cell Biology
    2. Genetics and Genomics

    Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

    Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
    Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
    1. Neuroscience

    Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

    Sunitha Subhramanian, Olga Bocharova ... Ilia V Baskakov
    In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynamic somatic migration and prolonged neuronal engagement.
    1. Cell Biology

    Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

    Po-Kai Wang, Keng-Hui Lin, Tang K Tang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cancer Biology
    2. Genetics and Genomics

    Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

    Jiadong Zhou, Xiao Albert Zhou ... Jiadong Wang
    A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
    1. Cancer Biology

    Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    Kyle Spinler, Michael Hamilton ... Tannishtha Reya
    A naturally occurring Musashi2 genetic translocation reported to occur in blast crisis chronic myelogenous leukemia patients can act as an oncogene and drive myeloid leukemia.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Atypical collective oscillatory activity in cardiac tissue uncovered by optogenetics

    Alexander S Teplenin, Nina N Kudryashova ... Tim De Coster
    Collective frequency-selective resonance in depolarised cardiac tissue enables reversible switching between quiescent and ectopic oscillations through hidden bi-stability, which is shaped by light intensity, illuminated area, and pacing frequency.
    1. Immunology and Inflammation

    A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

    Michaela T Reichmann, Liku B Tezera ... Paul T Elkington
    The deep evolutionary relationship between humans and Mycobacterium tuberculosis suggests latent infection may confer benefit, with important consequences for investigating and interpreting host–pathogen interactions.
    1. Biochemistry and Chemical Biology

    Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLD

    Jia He, Bo Chen ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    The PPE2 protein of Mycobacterium tuberculosis is responsible for the development of hyperglycemia and insulin resistance during tuberculosis

    Manoj Kumar Bisht, Vandana Maurya ... Sangita Mukhopadhyay
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing