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Ubiquitin accumulated on damaged lysosomes activates TAB–TAK1–IKK–NF-κB axis and remodels proteome through gene expression for cell survival and cell-cell communication.

Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme dimer.

Piezo proteins induce a curved protein-membrane nanodome with an excess area of about 40 nm² in tensionless membranes and resist tension-induced flattening with a force constant of about 60 pN/nm.

Recurrent neural network and its readout (cortex–striatum) can learn state representation and value using online random-weight feedback of temporal-difference reward-prediction-error (dopamine) through feedback alignment or biological non-negative-weight constraint-induced loose alignment.

Targeting Atoh1 for CRISPR/Cas9-mediated mutagenesis in sturgeon results in missing electroreceptors as well as mechanosensory hair cells, supporting conserved developmental mechanisms, whereas ectopic electrosensory organs develop after targeting mechanosensory-restricted Foxg1, suggesting FoxG1 directly or indirectly represses electrosensory organ formation.