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Page 27 of 1,860
    1. Cancer Biology

    Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma

    Gaoming Liao, Xinbin Yang ... Gang Xu
    BRCA1/2 mutations rewire the lung adenocarcinoma microenvironment through distinct immune programs, with BRCA1-linked type I interferon signaling and CD8+ T activation contrasting BRCA2-linked MHC-II antigen presentation and CD4+ T differentiation.
    1. Neuroscience

    Inhibitory columnar feedback neurons are involved in motion processing in Drosophila

    Miriam Henning, Madhura D Ketkar ... Marion Silies
    Inhibitory GABAergic feedback neurons tune direction-selective motion signals in Drosophila, sharpening behavioral responses to rapidly changing visual stimuli and expanding canonical feedforward models of visual motion computation.
    1. Ecology
    2. Physics of Living Systems

    Cognitive simplicity drives collective route improvements in homing pigeons

    Shoubhik Chandan Banerjee, Fritz A Francisco, Albert B Kao
    A navigational model exploring social learning strategies differing in cognitive complexity in homing pigeons shows that simple averaging sufficiently explains collective route improvements, without requiring cumulative cultural evolution.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    An engineered multi-step differentiation program in Escherichia coli for self-organized spatial patterning

    Emanuele Boni, Hélène Siboulet ... Yolanda Schaerli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cell Biology

    Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes

    Sritama Datta, Abhikarsh Gupta ... Monika Vig
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology

    Tatton-Brown-Rahman Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

    Gareth Chapman, Julianna J Determan ... Kristen L Kroll
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Epidemiology and Global Health

    Repurposed small molecule toxin inhibitors neutralise a diversity of venoms from the Neotropical viperid snake genus Bothrops

    Rachel H Clare, Adam Westhorpe ... Nicholas R Casewell
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology

    Endocardial TIE1 synergizes with TIE2 to regulate the atrial internal muscular network assembly

    Kai Ding, Beibei Xu ... Yulong He
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    TopoMetry systematically learns and evaluates the latent geometry of single-cell data

    David S Oliveira, Ana I Domingos, Licio A Velloso
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
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