Squidly enables efficient identification of enzyme catalytic residues by integrating functional hierarchies into a contrastive learning framework, requiring only protein sequences to produce scalable predictions across the known enzyme landscape.
Jenny A Hurcombe, Lusyan Dayalan ... Richard JM Coward
Simultaneously knocking down both the insulin and IGF1 receptor in the kidney podocyte is highly detrimental, affecting spliceosome function and gene transcription.
Computational modeling and human pilot study present a mechanistic framework explaining the capacity for transcutaneous tibial nerve stimulation to induce excitatory or inhibitory effects based on electrical stimulation frequency alone.
