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    1. Microbiology and Infectious Disease

    Caffeic acid phenethyl ester protects Clostridioides difficile infection by toxin inhibition and microbiota modulation

    Yan Guo, Yong Zhang ... Jiazhang Qiu
    Caffeic acid phenethyl ester treats Clostridioides difficile infection by neutralizing Clostridioides difficile toxin B and altering the gut microbiota and metabolites.
    1. Cell Biology
    2. Genetics and Genomics

    Kinesin-2 autoinhibition requires elbow phosphorylation

    Guanghan Chen, Zhengyang Guo ... Guangshuo Ou
    Phosphorylation of the kinesin-2 motor protein’s elbow region by NEKL-3 kinase maintains autoinhibition, enabling its transport to cilia for sensory function.
    1. Epidemiology and Global Health

    A sex-specific Mendelian randomization-phenome-wide association study of body mass index

    Zhu Liduzi Jiesisibieke, Io Ieong Chan ... C Mary Schooling
    Higher body mass index has a wide range of harmful health effects, which sometimes appear to be more pronounced in men, suggesting that higher BMI may be one of the factors contributing to differences in lifespan between men and women.
    1. Cancer Biology
    2. Cell Biology

    RUNX2 isoform II protects cancer cells from ferroptosis and apoptosis by promoting PRDX2 expression in oral squamous cell carcinoma

    Junjun Huang, Rong Jia, Jihua Guo
    Upregulated by HOXA10, RUNX2 isoform II transactivates PRDX2 expression and inhibits ferroptosis and apoptosis in oral squamous cell carcinoma.
    1. Neuroscience

    Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9

    Hey-Kyeong Jeong, Estibaliz Gonzalez-Fernandez ... Gareth M Thomas
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology

    Heterozygosity at a conserved candidate sex determination locus is associated with female development in the clonal raider ant (Ooceraea biroi)

    Kip D Lacy, Jina Lee ... Daniel JC Kronauer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity

    Samantha R Golf, Justin H Trotter ... Thomas C Südhof
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Neuroscience

    A stochastic explanation for observed local-to-global foraging states in Caenorhabditis elegans

    Andrew Margolis, Andrew Gordus
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

    Upneet K Sokhi, Ruoxi Yuan ... Lionel B Ivashkiv
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cancer Biology

    PA28γ promotes the malignant progression of tumor by elevating mitochondrial function via C1QBP

    Jiongke Wang, Yujie Shi ... Qianming Chen
    Revised
    Reviewed Preprint v4
    Updated
    • Important
    • Solid
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