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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the folding of PINK1 by the HSP90–CDC37 chaperone complex

    Kei Okatsu, Hayato Yamamoto ... Shuya Fukai
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression

    TAD boundary architecture and gene activity are uncoupled

    Faisal Almansour, Nadezda A Fursova ... Tom Misteli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    Cell surface localisation of GPI-anchored receptors in Trypanosoma brucei

    Sourav Banerjee, Nicola Minshall ... Mark Carrington
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Massively parallel reporter assay for mapping gene-specific regulatory regions at single-nucleotide resolution

    Alastair J Tulloch, Ryan Nicholas Delgado ... Constance L Cepko
    Integrated locus-specific and mutational MPRAs reveal regulatory modules and nucleotide determinants governing cell type-specific gene expression, providing a scalable framework for mapping cis-regulatory architecture.
    1. Neuroscience

    Flexible neural representations of abstract structural knowledge in the human entorhinal cortex

    Shirley Mark, Philipp Schwartenbeck ... Timothy E Behrens
    A novel fMRI method reveals that humans generalize task structure across non-aligned state spaces, showing entorhinal representations support flexible knowledge transfer.
    1. Plant Biology

    The influence of heavy metal stress on the evolutionary transition of teosinte to maize

    Jonathan Acosta-Bayona, Miguel Vallebueno-Estrada, Jean-Philippe Vielle-Calzada
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression

    UV irradiation alters TFAM binding specificity and compaction of DNA

    Dillon E King, Emily E Beard ... Joel N Meyer
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

    Jennifer Kosmatka, Cong Liu ... Amy E Keating
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    RNA Selectively Modulates Activity of Virulent Amyloid PSMα3 and Host Defense LL-37 via Phase Separation and Aggregation Dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology
    2. Neuroscience

    Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

    Daniel Beaudet, Christopher L Berger, Adam G Hendricks
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Solid
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