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Page 289 of 1,744
    1. Neuroscience

    Neural correlates of perceptual similarity masking in primate V1

    Spencer Chin-Yu Chen, Yuzhi Chen ... Eyal Seidemann
    Optical imaging from macaque monkeys performing a detection task reveals the contribution of neural populations in V1 to the phenomenon of camouflage, where detectability decreases with target-background similarity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

    Tien M Phan, Young C Kim ... Jeetain Mittal
    Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
    1. Immunology and Inflammation

    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

    Preksha Gaur, Yesheswini Rajendran ... Chittur Srikanth
    Rab7-mediated changes in goblet cell function play a crucial role in triggering gut inflammation during colitis.
    1. Immunology and Inflammation

    Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    Tatyana O Nakonechnaya, Bruno Moltedo ... Dmitriy M Chudakov
    Digitalized TCR repertoire-based view on antigenic specificity, plasticity, and tissue residence of regulatory T cells.
    1. Medicine

    Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast–osteoblast communication and potential clinical implications

    Valentina Daponte, Katrin Henke, Hicham Drissi
    A comprehensive review focusing on the role of osteoclasts as active regulators of bone homeostasis by influencing osteoblast function explores the currently known mechanisms and coupling factors involved in osteoclast–osteoblast communication and their potential as treatments for bone diseases.
    1. Neuroscience

    Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

    Jacob H Wilmot, Cassiano RAF Diniz ... Brian Joseph Wiltgen
    Locus coeruleus responses to salient environmental stimuli drive increases in hippocampal dopamine that are important for long-term memory formation during trace fear conditioning.
    1. Genetics and Genomics

    Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

    Pianpian Zhao, Zhifeng Sheng ... Hou-Feng Zheng
    Genetically determined type 2 diabetes (T2D) may not increase the risk of fracture, but managing T2D-related risk factors is crucial to prevent fracture in patients with T2D.
    1. Neuroscience

    Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure

    Rafael Naime Ruggiero, Danilo Benette Marques ... Joao Pereira Leite
    The enduring impacts of early-life seizures on cognition and behavior are not attributed to neuronal loss but to disrupted hippocampus-prefrontal cortex network dynamics, heightened neuroinflammation, and altered dopaminergic transmission.
    1. Developmental Biology

    Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal extension and steering via activating an autoregulatory factor, Mtss1

    Namsuk Kim, Yan Li ... Won-Jong Oh
    Repulsive guidance cues enhance a dual-functioning axonal trafficking facilitator, allowing navigating axons to ensure proper pathfinding by coordinating positive extension and negative steering during nervous system development.
    1. Neuroscience

    Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing

    Katrina Bartas, May Hui ... Kevin T. Beier
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid