Browse our latest research

Page 290 of 1,744
    1. Medicine

    Identification of Novel Syncytiotrophoblast Membrane Extracellular Vesicles Derived Protein Biomarkers in Early-onset Preeclampsia: A Cross-Sectional Study

    Toluwalase Awoyemi, Shuhan Jiang ... Manu Vatish
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Neuroscience

    Behavioral discrimination and olfactory bulb encoding of odor plume intermittency

    Ankita Gumaste, Keeley L Baker ... Justus Verhagen
    Mice are able to discriminate plume intermittency, which may be used for odor-guided navigation.
    1. Cancer Biology
    2. Structural Biology and Molecular Biophysics

    The molecular basis of Abelson kinase regulation by its αI-helix

    Johannes Paladini, Annalena Maier ... Stephan Grzesiek
    High-resolution NMR data and precise kinase activity assays on Abelson kinase bearing mutations in its αI-helix identify the αI-helix parts involved in disassembly of Abelson’s regulatory core and kinase activation.
    1. Neuroscience

    Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion model

    Behzad Yaghmaeian Salmani, Laura Lahti ... Thomas Perlmann
    Single nuclei RNA sequencing unmasks 16 variants of midbrain dopamine neurons within a continuum of their gene expression landscape and resolves their differential vulnerability.
    1. Genetics and Genomics

    The BTB-ZF gene Bm-mamo regulates pigmentation in silkworm caterpillars

    Songyuan Wu, Xiaoling Tong ... Fangyin Dai
    The BTB zinc finger gene Bm-mamo regulates melanin pigmentation in silkworm caterpillars from multiple aspects, including melanin synthesis, pigment granules maturation, and cuticle construction.
    1. Stem Cells and Regenerative Medicine

    A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes

    Magali Seguret, Patricia Davidson ... Jean-Sébastien Hulot
    A novel hydrogel-based platform uses a limited number of cells for tissue generation and offers unique advantages for high-throughput cardiac tissue culture.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    DePARylation is critical for S phase progression and cell survival

    Litong Nie, Chao Wang ... Junjie Chen
    DePARylation is essential for cell survival and thus poly(ADP-ribose) glycohydrolase (PARG) expression correlates with cytotoxicity induced by PARG inhibition, which will benefit the development of PARG inhibitors for cancer treatment.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations

    Maria L Adelus, Jiacheng Ding ... Casey E Romanoski
    Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists

    Danqi Sheng, Chen-Xi Yue ... Motoyuki Hattori
    Structural insights into the orthosteric inhibition and subtype specificity of P2X receptors by classical P2X antagonists facilitate the rational design of novel competitive antagonists for P2X receptors.
    1. Epidemiology and Global Health

    Higher ratio of plasma omega-6/omega-3 fatty acids is associated with greater risk of all-cause, cancer, and cardiovascular mortality: A population-based cohort study in UK Biobank

    Yuchen Zhang, Yitang Sun ... Kaixiong Ye
    Individuals with higher blood levels of omega-3 and omega-6 fatty acids, especially omega-3, are less likely to die, either from any cause, cancer or cardiovascular disease.