Browse our latest research

Page 318 of 1,755
    1. Cancer Biology

    Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

    Ryan R. Kawalerski, Mariana Torrente Gonçalves ... Luisa F. Escobar-Hoyos
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Ecology
    2. Epidemiology and Global Health

    Exploring factors shaping antibiotic resistance patterns in Streptococcus pneumoniae during the 2020 COVID-19 pandemic

    Aleksandra Kovacevic, David RM Smith ... Lulla Opatowski
    The mathematical modeling approach disentangles the impacts of the COVID-19 pandemic on antibiotic resistance in Streptococcus pneumoniae in the community setting and identifies the three most plausible driving mechanisms responsible for the observed trends in invasive isolates and pneumococcal carriage.
    1. Medicine
    2. Neuroscience

    Acute ampakines increase voiding function and coordination in a rat model of SCI

    Sabhya Rana, Firoj Alom ... Aaron D Mickle
    Ampakines demonstrate efficacy in enhancing bladder function in animal models of spinal cord injury, presenting promising prospects for innovative pharmacotherapy to alleviate post-injury bladder dysfunction.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    Identification of fallopian tube microbiota and its association with ovarian cancer

    Bo Yu, Congzhou Liu ... David N Fredricks
    A prospective study of intraoperative swab collections from 187 patients identified a putative fallopian tube microbiota and a clear shift in ovarian cancer patients compared to non-cancer patients.
    1. Neuroscience

    Interactions between circuit architecture and plasticity in a closed-loop cerebellar system

    Hannah L Payne, Jennifer L Raymond, Mark S Goldman
    A comprehensive modeling approach reconciles experimental observations with classic plasticity mechanisms in the cerebellar cortex, demonstrating how learning-related changes in neural activity can appear to contradict the sign of the underlying plasticity when feedback is present.
    1. Neuroscience

    Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling

    Yuval Orsher, Ariel Rom ... Mark Shein-Idelson
    Multi-electrode recordings and modeling work indicate that sequentially activated discrete modules of spiking neurons may appear as traveling waves in low spatial resolution measurements, suggesting caution when interpreting phase delay measurements as continuously propagating wavefronts.
    1. Cell Biology

    Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

    Ramon Lorenzo D. Labitigan, Adrian L. Sanborn ... Julie A. Theriot
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology

    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells

    Marta Grzonka, Hisham Bazzi
    Unlike mouse embryos, mouse embryonic stem cells are able to use a SAS-6-independent pathway for imperfect centriole biogenesis that is associated with a rich centrosomal milieu and robust PLK4 activity.
    1. Structural Biology and Molecular Biophysics

    The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    Johannes N Greve, Anja Marquardt ... Dietmar J Manstein
    Mutation E334Q in cytoskeletal γ-actin leads to impaired interaction of actin filaments with actin-binding proteins belonging to the myosin and ADF/cofilin families.