In reporter mice, subtypes of peripheral neurons show different regenerative capabilities after nerve injury and activate common pathways but also specific ones, indicating a different intrinsic growth response among them.
Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson
A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
Disruption of the Clock gene in the cnidarian Nematostella vectensis revealed its essential role in circadian rhythm maintenance and uncovered a compensatory light-response pathway, advancing our comprehension of circadian regulation in non-bilaterian animals.
Mariana I Tsap, Andriy S Yatsenko ... Halyna R Shcherbata
Drosophila model reveals that NTE/SWS-associated neurodegeneration is a lysosomal storage disorder accompanied by a leaky brain permeability barrier, abnormal fatty acid metabolism, and inflammation.
Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
Yiyi Chen, Laimdota Zizmare ... Christoph Trautwein
Targeted manipulations on organotypic cultures show that the retina switches between at least four different metabolic pathways, each with different yields and kinetics, to dynamically adapt to momentaneous energy needs.
Ryan T Bell, Harutyun Sahakyan ... Eugene V Koonin
Bacterial Type IV restriction-modification systems display remarkable, previously unnoticed diversity of complex gene and domain architectures, and are predicted to couple antiphage immunity with the abortive infection form of defense.
