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    1. Immunology and Inflammation
    2. Neuroscience

    Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans

    Benson Otarigho, Anna Frances Butts, Alejandro Aballay
    Molecular and genetics approaches reveal a dual regulatory role of neuronal G-protein-coupled receptor NPR-15 in both immunity and avoidance behavior, independent of aerotaxis, mediated by amphid sensory neurons, ASJ.
    1. Stem Cells and Regenerative Medicine

    Ex vivo expansion potential of murine hematopoietic stem cells is a rare property only partially predicted by phenotype

    Qinyu Zhang, Rasmus Olofzon ... David Bryder
    Application of a polyvinyl alcohol-based culture system reveals extensive differentiation but simultaneous robust murine hematopoietic stem cell (HSC) expansion, which are characterized by phenotypic, functional, and molecular properties shared with freshly isolated bone marrow HSCs.
    1. Neuroscience

    Hyperactivity of mTORC1- and mTORC2-dependent signaling mediates epilepsy downstream of somatic PTEN loss

    Erin R Cullen, Mona Safari ... Matthew C Weston
    Epilepsy caused by focal Pten deletion is only prevented when both mTOR complexes are simultaneously inhibited, but not alone, suggesting they play independent roles in the development of epilepsy.
    Version of Record
    Short Report
    • Important
    • Convincing
    1. Cell Biology

    The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

    Hugo Siegfried, Georges Farkouh ... Mélina L Heuzé
    Depletion of VAPA in cancer cells induces defects in actin organization, adhesion dynamics and cell migration, together with a perturbation of phosphoinositide levels at the plasma membrane and a lack of anchoring of ER-PM contact sites to focal adhesions.
    1. Neuroscience

    Dorsolateral prefrontal activity supports a cognitive space organization of cognitive control

    Guochun Yang, Haiyan Wu ... Jiefeng Jiang
    The dorsolateral prefrontal cortex represents different conflict types within an organized cognitive space of cognitive control, positioning more similar conflict types closer together.
    1. Neuroscience

    Excitatory neurons in stratum radiatum provide an alternative pathway for excitation flow that escapes perisomatic inhibition

    Julia Lebedeva, David Jappy ... Andrei Rozov
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling

    Peibo Xu, Jian Peng ... Yuejun Chen
    A multiplexed retrograde virus tracing method captures single-neuron projectome and transcriptome simultaneously.
    1. Cancer Biology

    Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

    Tiesuo Zhao, Pengkun Wei ... Huijie Jia
    A cellular experiment and animal model reveals that nifuroxazide can inhibit the expression of PD-L1 through the proteasome pathway, rather than at the genetic level.
    1. Plant Biology

    Rapid translocation of NGR proteins driving polarization of PIN-activating D6 protein kinase during root gravitropism

    Ivan Kulich, Julia Schmid ... Jiří Friml
    Negative Gravitropic Response of roots (NGRs), pivotal for root gravitropic bending, are indispensable for the gravity-induced translocation of D6 protein kinase, a key regulator of PIN3 auxin efflux carrier activity.
    1. Medicine
    2. Neuroscience

    Gene–environment pathways to cognitive intelligence and psychotic-like experiences in children

    Junghoon Park, Eunji Lee ... Jiook Cha
    Genetics, socioeconomic conditions, and family and school environments influence cognitive intelligence in children, and this impact may lead to the individual variability of the current and future PLEs.