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Bone marrow-derived macrophages reveal that leucine promotes M2 polarization through mTORC1/LXRα/Arg1 signaling pathway, establishing a fundamental link between metabolism and immunity.

CCDC146 is a structural component of the flagellum in sperm, located in the doublet microtubules of the axoneme, whose absence leads to multiple morphological anomalies of the flagellum.

NetTCR 2.2 demonstrates advances in predicting MHC-peptide-TCR interactions through integration of pan- and peptide-specific training strategies, loss-scaling and sequence similarity scoring.

Obesogenic diet intake throughout adolescence impairs different types of memory through overactivation of specific hippocampal efferent pathways and targeting these overactive pathways has therapeutic potential.

High-quality fluorescence live-cell and single molecule imaging via computer-controlled, user-assembled microscope that fits in incubator, can in large parts be 3D printed and employs open source software and electronics.

PSTPIP2 reduced IL-19 secretion by inhibiting activation of the NF-κB pathway in renal tubular epithelial cells (RTECs), reducing the generation of neutrophil extracellular trap, which can participate in both aristolochic acid I-induced renal injury and apoptosis in RTECs.

Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, the mechanical forces separating Drosophila microtubule asters are revealed.

CryoEM reveals the structure of a two-component archaeal S-layer, which sheds new light on archaeal cell biology.

A neural circuit model reveals how biological brains may implement rapid learning and navigation in complex spaces.