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Caffeine modulates the genetic risk for cardiovascular disease through changes in target gene expression, likely due to regulation of transcription factor binding.

EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.

Physical interactions are a minor contributor to the correlations in evolutionary rate over time that are observed between co-functional proteins.

A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.

An experimental animal model provides further insights into the host and viral mechanisms underlying airborne transmission of SARS-CoV-2.

The dynamics of Sirtuin 6 binding to the nucleosome shed light on how it is able to deacetylate histone H3 lysines close to the core, including K27.

A useful single-cell resource provides the prenatal macaque different cell types’ gene expression profiles in the parietal cerebral cortex lobe.

Prompt contact tracing (testing at the beginning instead of at the end of isolation period) of individuals with COVID-19 in the community reduces delays in contact tracing, increases identification of source of infection, and reduces transmission rates in educational settings.

Computational and experimental structural biology reveals the structural repertoire of effector proteins produced by Fusarium oxysporum f. sp. lycopersici during infection of tomato.

Expression of mTORC1 pathway gene variants in mouse medial prefrontal cortex leads to shared alterations in pyramidal neuron morphology, positioning, and membrane excitability but different changes in excitatory synaptic transmission.