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High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.

Deletion of β-catenin in Col2⁺ progenitor cells shifts their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of glucocorticoid-induced osteonecrosis of the femoral head in adult mice.

Electrophysiological recordings and optogenetic manipulations revealed the distinct roles that acetylcholine can have on the amygdala and prefrontal cortex in a Window of Opportunity Task.

The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.

SP1 serves as an important transcription factor in the regulation of ACE2 expression.

Histone, PCNA, and DNA binding are essential for CAF-1 functions in preventing DNA damage during DNA replication in Schizosaccharomyces pombe, while its C-terminal domain specifies distinct cellular processes.

NMR spectroscopy, dCypher assays, and CUT&RUN demonstrate that occlusion of the histone tails in the nucleosome context alters histone PTM specificity for a tandem of reader domains.

First systemic lysosomal proteomes in association with longevity and tissue specificity in C. elegans uncover lysosomal heterogeneity across multiple scales and provide valuable resources for understanding how lysosomes modulate signal transduction, organelle communication, tissue physiology, and organism longevity.

Orbitofrontal cortex lesions impact the neural correlates of detection of auditory regularity violation at two hierarchical levels of rule abstraction, providing a novel perspective on the role of the orbitofrontal cortex in auditory predictive processing.

Children with ASD showed a significant divergence in gaze patterns compared to typically developing children, intensifying over early childhood, with implications for developmental and adaptive functioning.