Browse our latest research

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    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

    Foteini Karapanagioti, Úlfur Águst Atlason ... Sebastian Obermaier
    Secondary active transporters can evolve to accommodate a broader range of substrates without losing their original substrate specificities.
    1. Developmental Biology

    Obox4 promotes zygotic genome activation upon loss of Dux

    Youjia Guo, Tomohiro Kitano ... Haruhiko Siomi
    Analysis of mouse zygotic genome activation (ZGA) reveals that a mis-annotated multicopy homeobox gene Obox4 functions redundantly with Dux to promote ZGA.
    1. Neuroscience

    Fast burst fraction transients convey information independent of the firing rate

    Richard Naud, Xingyun Wang ... Guy Doron
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Chromatin regulator Kdm6b is required for the establishment and maintenance of neural stem cells in mouse hippocampus

    Eugene Gil, Sung Jun Hong ... Daniel A. Lim
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Eugenol mimics exercise to promote skeletal muscle fiber remodeling and myokine IL-15 expression by activating TRPV1 channel

    Tengteng Huang, Xiaoling Chen ... Zhiqing Huang
    Eugenol has the potential as a novel exercise mimetic, and TRPV1 may represent a promising target for the development of exercise mimetics.
    1. Neuroscience

    Visuo-motor updating in individuals with heightened autistic traits

    Antonella Pomè, Eckart Zimmermann
    Efference copy dysfunctions in heightened autistic traits impair the use of eye movement information for spatial representation and object localization.
    1. Computational and Systems Biology
    2. Medicine

    The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
    1. Neuroscience

    Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear

    Eugenio Manassero, Giulia Concina ... Benedetto Sacchetti
    Implicit defensive reactions to a learned threat-predictive cue and novel stimuli may be significantly downregulated through a repetitive transcranial magnetic stimulation procedure over the medial anterior prefrontal cortex in humans.
    1. Genetics and Genomics

    Discovering non-additive heritability using additive GWAS summary statistics

    Samuel Pattillo Smith, Gregory Darnell ... Lorin Crawford
    Computational analysis reveals that additive summary statistics from genome-wide association studies can provide evidence of non-additive heritability in complex traits.
    1. Microbiology and Infectious Disease

    Rapid bacterial evaluation beyond the colony forming unit in osteomyelitis

    Qi Sun, Kimberley Huynh ... Dongqing Yang
    This time-shortened work flow improves sensitivity and specificity for the identification of bacteria in bone infections independently of bacterial culturability.
    Version of Record
    Short Report
    • Fundamental
    • Compelling