NAD+ exhibits profound therapeutic effects in experimental septic shock models by dampening the systemic inflammatory response and leading to improved survival.
An RNAi screen in mouse hippocampal neuronal cell line targeting epigenetic regulators revealed a novel neuroprotection of Prmt5 and uncovered its nucleus translocation feature and epigenetic mechanism in cerebral ischemia.
Pradeep Kumar, Ankit Roy ... Rajan Sankaranarayanan
Genetic, biochemical, and bioinformatic analyses reveal how expanding metabolic repertoire interferes with fundamental processes like protein synthesis inside cells and the role of D-aminoacyl-tRNA deacylase2 in protecting these processes during terrestrialisation.
Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
Region of Attainable Redaction analysis allows scientists to estimate the potential impacts of redaction in biomedical science, helping to uncover potentially spurious or non-robust results.
A novel compartment model identifies the impact of malaria strain diversity on biogeographic drug resistance patterns, supported by empirical evidence.
