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    1. Microbiology and Infectious Disease

    Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

    Abhishek Jamwal, Cristina F Constantin ... Matthew K Higgins
    The most effective growth-neutralising antibodies which target the PfRH5 protein from a malaria parasite function by preventing the parasite from binding to basigin-containing membrane protein complexes on human erythrocytes.
    1. Structural Biology and Molecular Biophysics

    Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

    Márton A Simon, Iordan Iordanov ... László Csanády
    Functional studies on CFTR anion channels harboring combinations of catalytic site mutations in the active ATPase site reveal the true stability of the prehydrolytic open-pore state as well as nucleotide-binding domain interface features that are unique to human CFTR.
    1. Cell Biology
    2. Physics of Living Systems

    A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

    Xarxa Quiroga, Nikhil Walani ... Pere Roca-Cusachs
    Cell stretch release generates plasma membrane (PM) evaginations of ≈100 nm, triggering a local event of actin polymerization that flattens and recovers PM shape.
    1. Epidemiology and Global Health

    A rapid review of COVID-19’s global impact on breast cancer screening participation rates and volumes from January to December 2020

    Reagan Lee, Wei Xu ... Jonine Figueroa
    A reduction in breast screening participation volume during COVID-19 that differed by region and healthcare setting was observed in a rapid review of 26 studies globally, suggesting monitoring of screening access by disadvantaged groups to reduce disparities.
    1. Biochemistry and Chemical Biology

    Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

    Michele Brischigliaro, Alfredo Cabrera-Orefice ... Erika Fernández-Vizarra
    Inducing the formation of mitochondrial respiratory chain supercomplexes in Drosophila melanogaster, where they are normally absent, does not have any noticeable impact in the function of the respiratory chain.
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Microbiology and Infectious Disease

    Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

    Nikol Kadeřábková, R. Christopher D. Furniss ... Despoina A.I. Mavridou
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Transcriptional control of compartmental boundary positioning during Drosophila wing development

    Gustavo Aguilar, Michèle Sickmann ... Martin Müller
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses

    Sevim Kahraman, Kimitaka Shibue ... Rohit N Kulkarni
    Live human pancreatic α-cells can be purified effectively using zinc-based reaction probe diacetylated Zinpyr1 and cultured as pseudoislets without losing their viability and function.
    1. Genetics and Genomics

    The DBL-1/TGF-β signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans

    Bhoomi Madhu, Mohammed Farhan Lakdawala, Tina L Gumienny
    The C. elegans canonical DBL1/TGFβ signaling pathway is not only regulated in response to bacterial challenges, but also appropriately tailors behaviors and molecular immune responses to bacterial challenges, and animals lacking DBL1 respond to specific bacteria as more harmful.