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    1. Microbiology and Infectious Disease

    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation

    Robert J Bastidas, Mateusz Kędzior ... Raphael H Valdivia
    Genetic and biochemical analyses show that Chlamydia protects secreted effectors necessary for its exit from infected cells, preventing them from undergoing ubiquitination and degradation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping the architecture of the initiating phosphoglycosyl transferase from S. enterica O-antigen biosynthesis in a liponanoparticle

    Greg J Dodge, Alyssa J Anderson ... Barbara Imperiali
    Structural, functional, and bioinformatics analyses further understanding of the initial steps of prokaryotic glycoconjugate biosynthesis catalyzed by the large class of membrane-embedded monotopic phosphoglycosyl transferase superfamily.
    1. Neuroscience

    Overnight fasting facilitates safety learning by changing the neurophysiological response to relief from threat omission

    Silvia Papalini, Tom Beckers ... Bram Vervliet
    Not revised
    Reviewed Preprint v1
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    • Incomplete
    1. Evolutionary Biology
    2. Plant Biology

    Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant

    Lei Zhao, Wei Zhou ... Hong-Tao Li
    Computational analyses, for the first time in plants, reveal how male-biased genes evolve faster than female-biased and unbiased genes.
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

    Nikolaos Vardalakis, Amélie Aussel ... Fabien B Wagner
    Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.
    1. Computational and Systems Biology

    Structural assembly of the bacterial essential interactome

    Jordi Gómez Borrego, Marc Torrent Burgas
    A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Heat stress-induced activation of MAPK pathway attenuates Atf1-dependent epigenetic inheritance of heterochromatin in fission yeast

    Li Sun, Libo Liu ... Quan-wen Jin
    Fission yeast loses its heterochromatin stability at mating-type locus under high temperature due to compromised binding between heterochromatin protein Swi6HP1 and Atf1.
    1. Plant Biology

    The tRNA thiolation-mediated translational control is essential for plant immunity

    Xueao Zheng, Hanchen Chen ... Shunping Yan
    The transfer RNA thiolation modification is required for the efficient translation of the master immune regulator NPR1 in plants.
    1. Structural Biology and Molecular Biophysics

    Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

    Michael J Currie, James S Davies ... Rachel A North
    Structure of the dimeric Haemophilus influenzae TRAP transporter (SiaQM) reveals two Na+ sites, the substrate-binding site and lipid-binding sites, and weak but promiscuous binding of SiaP to SiaQM.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

    KM Rifat Faysal, James C Walsh ... Till Böcking
    The anti-HIV drug lenacapavir breaks the HIV capsid by stabilising regions of low curvature at the expense of maintaining a closed shell, leading to loss of viral DNA synthesis and inhibition of infection.